Altered slow wave activity in major depressive disorder with hypersomnia: a high density EEG pilot study
| Autor: | Tim Wanger, Michael Goldstein, David T. Plante, Jeff J. Guokas, Giulio Tononi, Eric C. Landsness, Ruth M. Benca, Michael J. Peterson |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Polysomnography Neuroscience (miscellaneous) High density Pilot Projects Disorders of Excessive Somnolence Audiology Electroencephalography Brain mapping behavioral disciplines and activities Article Young Adult mental disorders medicine Humans Radiology Nuclear Medicine and imaging Major complication Young adult Psychiatry Depression (differential diagnoses) Psychiatric Status Rating Scales Brain Mapping Depressive Disorder Major medicine.diagnostic_test Brain medicine.disease Brain Waves Psychiatry and Mental health Major depressive disorder Female Psychology |
| Zdroj: | Psychiatry research. 201(3) |
| ISSN: | 0165-1781 |
| Popis: | Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age- and sex-matched MDD subjects without hypersomnia (HYS-) and healthy controls (n=7 for each group). After correction for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS- subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using an adequately powered prospective design is indicated to confirm these findings. |
| Databáze: | OpenAIRE |
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