Influence of Angiotensin I-Converting Enzyme Gene Polymorphism on Hepatocellular Carcinoma Risk in China
| Autor: | Fang Yuan, Meili Lv, Lu-Shun Zhang, Miao Liao, ChongJie Zhang, Hong-Yu Li |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male China medicine.medical_specialty Carcinoma Hepatocellular Genotype Nitric Oxide Synthase Type III Peptidyl-Dipeptidase A Biology Gastroenterology law.invention INDEL Mutation Risk Factors law Enos Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele Molecular Biology Gene Polymerase chain reaction Aged Polymorphism Genetic Inflammation & Host Response to Infection Liver Neoplasms Intron Cell Biology General Medicine Middle Aged biology.organism_classification medicine.disease Molecular biology Variable number tandem repeat Hepatocellular carcinoma Disease Progression Female |
| Zdroj: | DNA and Cell Biology. 32:268-273 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2012.1910 |
| Popis: | Growing evidence suggests that the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes are associated with risk in a wide range of cancers. The objective of this study was to examine whether two DNA polymorphisms at the ACE insertion/deletion (I/D) and the variable number of tandem repeats in NOS intron 4 (4a/4b) were linked to the risk of developing hepatocellular carcinoma (HCC) in a Chinese population. The polymorphisms at ACE I/D and eNOS 4a/4b were genotyped in 293 HCC patients and 384 healthy control subjects using polymerase chain reaction. The frequencies of the D allele (p=0.003, OR=0.72, 95% CI=0.58–0.90) in the ACE gene of HCC patients were significantly different from the healthy controls, and a significantly decreased HCC risk was associated with the DD genotype in both the recessive (p |
| Databáze: | OpenAIRE |
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