Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
| Autor: | Déa Maria Serra Villa-Verde, Suse Dayse Silva-Barbosa, Elizangela Silva-Monteiro, Ana Rosa Pérez, Natalia Guiñazú, Oscar Bottasso, Daniella Arêas Mendes-da-Cruz, Maria del Pilar Aoki, Susana Gea, Wilson Savino |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Chemokine
Trypanosoma cruzi Endocrinology Diabetes and Metabolism medicine.medical_treatment Immunology Parasitemia medicine.disease_cause General Biochemistry Genetics and Molecular Biology Autoimmunity Mice Immune system Immunity medicine Animals Humans Immunology and Allergy Chagas Disease Immunity Cellular Mice Inbred BALB C biology Macrophages Macrophage Activation medicine.disease biology.organism_classification Acquired immune system Immunity Innate Extracellular Matrix Cytokine biology.protein Chemokines Cell Adhesion Molecules |
| Zdroj: | Cytokine & Growth Factor Reviews. 18:107-124 |
| ISSN: | 1359-6101 |
| DOI: | 10.1016/j.cytogfr.2007.01.010 |
| Popis: | Pathophysiology of Chagas' disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production, nitric oxide synthesis, and consequent control of parasitemia and mortality. Cell-mediated immunity in Trypanosoma cruzi infection is also modulated by cytokines, but in addition to parasite-specific responses, autoimmunity can be also triggered. Importantly, cytokines may also play a role in the cell-mediated immunity of infected subjects. Finally, leukocyte influx towards target tissues is regulated by cytokines, chemokines, and extracellular matrix components which may represent potential therapeutic targets in infected patients. Here we will discuss recent findings on the role of cytokines, chemokines and extracellular matrix components in the regulation of innate and adaptive immunity during T. cruzi infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect