Comprehensive Assessment of Serious Adverse Events Following Immunization by Health Care Providers
| Autor: | Philip LaRussa, Claudia Vellozzi, Neal A. Halsey, Colin D. Marchant, Jane Gidudu, Kathryn M. Edwards, Tyler Reimschisel, Nicola P. Klein, Roger Baxter, Cornelia L. Dekker, Melvin Berger, S. Elizabeth Williams, Peter D. Donofrio |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
MMR Measles mumps and rubella Isolation (health care) Health Personnel VAERS Vaccine Adverse Event Reporting System Risk Assessment Article AEFI Adverse event following immunization Intervention (counseling) Health care medicine Humans book ADEM Acute disseminated encephalomyelitis business.industry Public health International health CISA Clinical Immunization Safety Assessment Vaccination Immunization Family medicine Pediatrics Perinatology and Child Health Pediatric Infectious Disease book.journal business |
| Zdroj: | The Journal of Pediatrics |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2013.01.028 |
| Popis: | From the Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, TN; Kaiser Permanente Vaccine Study Center, Oakland, CA; Division of Pediatric Infectious Diseases, Columbia University, New York City, NY; Department of International Health, Disease Prevention and Control Program, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Division of Pediatric Infectious Diseases, Stanford University School of Medicine, M any events occurring after vaccination have been attributed to vaccines, when in fact the associationwas often due to chance. However, as with any medical intervention, there are times when adverse events are caused by immunizations. Distinguishing which events are causally related to vaccine, rather than coincidental events, is a challenge for the pediatrician and amajor focus of vaccine safety science. Consider a childwho presents with asepticmeningitis after immunization. Because of the temporal relationship, one may suspect the immunizations as the cause, yet subsequent isolation of enterovirus from cerebrospinal fluid implicates the enteroviral infection instead. The term adverse event following immunization (AEFI) is defined as any untoward event that occurs after immunization, regardless of causal association. AEFI is the preferred notation to describe such clinical events because the term is free from implications regarding causal relationship and favors an openmind about the role of immunizations.AEFIs are a commonpart of routine clinical practice. The Clinical Immunization Safety Assessment (CISA) network has reviewedmany individual cases of AEFIs and found that when a comprehensive investigation for alternative etiologies of the AEFI is completed, other causes for the event can often be identified. Yet, such comprehensive evaluations are rarely performed. We describe a stepwise approach to the comprehensive assessment of serious AEFIs by health care providers. The main objective is to highlight the important role that health care providers play in this effort by actively evaluating for the most likely causes of serious events when they occur after immunization. |
| Databáze: | OpenAIRE |
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