Bioinformatics analysis of candidate genes and potential therapeutic drugs targeting adipose tissue in obesity
| Autor: | Yun Yu, Yu-Han Zhang, Liang Liu, Ling-Ling Yu, Jun-Pei Li, Jing-an Rao, Feng Hu, Ling-Juan Zhu, Hui-Hui Bao, Xiao-Shu Cheng |
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| Rok vydání: | 2021 |
| Předmět: |
Histology
QH573-671 Physiology Gene Expression Profiling biomarkers Computational Biology drug-gene interaction bioinformatics Cell Biology RC648-665 adipocyte Diseases of the endocrine glands. Clinical endocrinology Adipose Tissue Pharmaceutical Preparations tissue-specific gene expression QP1-981 Humans Gene Regulatory Networks Obesity Cytology Research Article Research Paper |
| Zdroj: | Adipocyte article-version (VoR) Version of Record Adipocyte, Vol 11, Iss 1, Pp 1-10 (2022) |
| ISSN: | 2162-397X 2162-3945 |
| DOI: | 10.1080/21623945.2021.2013406 |
| Popis: | Obesity is a complex medical condition that affects multiple organs in the body. However, the underlying mechanisms of obesity, as well as its treatment, are largely unexplored. The focus of this research was to use bioinformatics to discover possible treatment targets for obesity. To begin, the GSE133099 database was used to identify 364 differentially expressed genes (DEGs). Then, DEGs were subjected to tissue-specific analyses and enrichment analyses, followed by the creation of a protein-protein interaction (PPI) network and generation of a drug-gene interaction database to screen key genes and potential future drugs targeting obesity. Findings have illustrated that the tissue-specific expression of neurologic markers varied significantly (34.7%, 52/150). Among these genes, Lep, ApoE, Fyn, and FN1 were the key genes observed in the adipocyte samples from obese patients relative to the controls. Furthermore, nine potential therapeutic drugs (dasatinib, ocriplasmin, risperidone, gemfibrozil, ritonavir, fluvastatin, pravastatin, warfarin, atorvastatin) that target the key genes were also screened and selected. To conclude the key genes discovered (Lep, ApoE, Fyn, and FN1), as well as 9 candidate drugs, could be used as therapeutic targets in treating obesity. |
| Databáze: | OpenAIRE |
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