Reduced activation to implicit affect induction in euthymic bipolar patients: An fMRI study
| Autor: | Belinda Ivanovski, Adrian M. Owen, Ron Shnier, Perminder S. Sachdev, Jim Lagopoulos, Gin S Malhi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Bipolar I disorder Precuneus Prefrontal Cortex Audiology Gyrus Cinguli Cuneus mental disorders medicine Humans Bipolar disorder Dominance Cerebral Prefrontal cortex Evoked Potentials Brain Mapping medicine.diagnostic_test Brain Electroencephalography Inferior parietal lobule Middle Aged Verbal Learning medicine.disease Magnetic Resonance Imaging Frontal Lobe Semantics Affect Psychiatry and Mental health Clinical Psychology Memory Short-Term medicine.anatomical_structure Posterior cingulate Parahippocampal Gyrus Female Arousal Psychology Functional magnetic resonance imaging psychological phenomena and processes Cognitive psychology |
| Zdroj: | Journal of Affective Disorders. 97:109-122 |
| ISSN: | 0165-0327 |
| Popis: | Objective To examine whether euthymic bipolar patients engage similar or contrasting brain regions as healthy subjects when responding to implicit affect induction. Methods The study examined 10 euthymic patients with bipolar I disorder, and 10 age- and gender-matched healthy subjects using event-related functional magnetic resonance imaging (fMRI) while subjects engaged in a modified word-based memory task designed to implicitly evoke negative, positive or no affective change. The activation paradigm involved nominating whether a target word was contained within a previously presented word list using specified response keys. Results The fMRI task produced significantly greater activation in healthy subjects as compared to patients in response to both negative and positive affect in the anterior and posterior cingulate, medial prefrontal cortex, middle frontal and right parahippocampal gyri. Only negative affect produced significantly greater activation in the postcentral gyrus, inferior parietal lobule, thalamus and putamen and only positive affect achieved the same in the precentral, superior temporal and lingual gyri, precuneus, cuneus, caudate, pons, midbrain and cerebellum. There were no brain regions in which responses were greater in patients as compared to healthy subjects. There were no statistically significant differences between the groups with respect to speed or accuracy. Conclusions Diminished prefrontal, cingulate, limbic and subcortical neural activity in euthymic bipolar patients as compared to healthy subjects is suggestive of emotional compromise that is independent of cognitive and executive functioning. This finding is of clinical importance and has implications both for the diagnosis and treatment of bipolar disorder. Future studies should aim to replicate these findings and examine the development of bipolar disorder, investigating in particular the effects of medication. |
| Databáze: | OpenAIRE |
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