Sinoaortic Denervation Prevents Enhanced Heat Loss Induced By Central Cholinergic Stimulation During Physical Exercise
| Autor: | Andrea Siqueira Haibara, Luiz Oswaldo Carneiro Rodrigues, Nilo R. V. Lima, Bernardo Moreira Soares Oliveira, Cândido C. Coimbra, Juliana B. Guimarães, Milene R. M. Lima, Samuel Penna Wanner, Washington Pires, Daniel Carvalho de Lima |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Baroreceptor Physostigmine Statistics as Topic Hemodynamics Blood Pressure Physical Therapy Sports Therapy and Rehabilitation Physical exercise Stimulation Autonomic Nervous System Body Temperature Heart Rate Internal medicine Physical Conditioning Animal Heart rate Animals Medicine Orthopedics and Sports Medicine Sinoaortic denervation Rats Wistar Molecular Biology Injections Intraventricular Sinoatrial Node Denervation Analysis of Variance Dose-Response Relationship Drug business.industry General Neuroscience Heat losses Thermoregulation Acetylcholine Rats Endocrinology Blood pressure Anesthesia Exercise Test Cholinergic Neurology (clinical) Cholinesterase Inhibitors business Developmental Biology Body Temperature Regulation |
| Zdroj: | Medicine & Science in Sports & Exercise. 42:112 |
| ISSN: | 0195-9131 |
| DOI: | 10.1249/01.mss.0000389495.17338.ac |
| Popis: | The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham denervation (SHAM) and then fitted with a chronic guide cannula into the lateral cerebral ventricle. After 2 weeks, a catheter was implanted into the ascending aorta, and a temperature sensor was implanted into the peritoneal cavity. Two days later, the rats were submitted to exercise on a treadmill at 18 m/min until fatigued. Thermoregulatory and cardiovascular responses were measured after injection of 2 μL of 10mM physostigmine (Phy) or 0.15M NaCl solution (Sal) into the cerebral ventricle. In SHAM rats, Phy injection induced a greater exercise-induced increase in blood pressure and lower increase in heart rate than Sal treatment. In the SAD group, the attenuation of heart rate in response to Phy was blocked despite an exaggerated increase in blood pressure. SHAM rats treated with Phy had a higher increase in tail skin temperature compared to Sal injection (31.9 ± 0.4 °C Phy-SHAM vs. 30.1 ± 0.6 °C Sal-SHAM, 5 min after injection; p |
| Databáze: | OpenAIRE |
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