Investigation of Interactive Activity of Electro-Acupuncture on Pharmacokinetics of Sildenafil and Their Synergistic Effect on Penile Blood Flow in Rats

Autor: Andy C. Huang, Navneet Kumar Dubey, Tung Hu Tsai, Allen W. Chiu, Yung Yi Cheng, Kuei Ying Yeh
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.drug_mechanism_of_action
Electroacupuncture
medicine.medical_treatment
Vasodilator Agents
sildenafil
Pharmacology
lcsh:Chemistry
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
lcsh:QH301-705.5
Spectroscopy
Penile Erection
General Medicine
Computer Science Applications
030220 oncology & carcinogenesis
Area Under Curve
cardiovascular system
Administration
Intravenous
Phosphodiesterase 5 inhibitor
pharmacokinetics
acupuncture
Sildenafil
erectile dysfunction
penile blood flow
Catalysis
Article
Sildenafil Citrate
Catheterization
Inorganic Chemistry
03 medical and health sciences
Pharmacokinetics
medicine
Animals
Physical and Theoretical Chemistry
Molecular Biology
Analysis of Variance
business.industry
Organic Chemistry
Therapeutic effect
Blood flow
Phosphodiesterase 5 Inhibitors
medicine.disease
electro-acupuncture
Rats
respiratory tract diseases
Erectile dysfunction
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Pharmacodynamics
business
030217 neurology & neurosurgery
Penis
Zdroj: International Journal of Molecular Sciences
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2153 (2018)
ISSN: 1422-0067
DOI: 10.3390/ijms19082153
Popis: Erectile dysfunction (ED) is a disorder found in males throughout the world, which negatively affects relationships with partners with advancing age. Hence, in this study, we tested a combined novel treatment of electro-acupuncture (EA) and sildenafil citrate against ED. In addition to EA therapy, the sildenafil citrate, a phosphodiesterase 5 inhibitor, is a widely recognized drug that has achieved considerable success in the treatment of ED. However, the combined effect of both the EA and sildenafil has not yet been investigated. Hence, we aimed to examine the effect of EA on the pharmacokinetics and pharmacodynamics of sildenafil in rat plasma. The pharmacokinetic parameters were determined using ultra performance liquid chromatography (UPLC) after EA and sildenafil administration (10 mg/Kg). Following this, the pharmacodynamics was studied via blood flow pattern using developing Doppler images of the lower body and penis. The pharmacokinetic studies demonstrated that sildenafil significantly increases by administration of low-frequency EA. Further, the pharmacodynamic studies using Doppler imaging revealed an elevated blood flow in rat penis compared with lower body during combined treatment of sildenafil and low-frequency EA. These data indicate a synergistic therapeutic effect of EA and sildenafil for the treatment of ED.
Databáze: OpenAIRE
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