Presence of parvovirus B19 DNA in chronic urticaric and healthy human skin
| Autor: | K Lammintausta, Tytti Vuorinen, S Nikkari, Pirkko Kotilainen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Adolescent Urticaria viruses Human skin Antibodies Viral Polymerase Chain Reaction Virus Parvoviridae Infections immune system diseases hemic and lymphatic diseases Virology Immunopathology Parvovirus B19 Human medicine Humans Aged Skin Parvoviridae biology medicine.diagnostic_test business.industry Parvovirus virus diseases Middle Aged biology.organism_classification Infectious Diseases Immunoglobulin G Chronic Disease DNA Viral Immunology Skin biopsy Etiology biology.protein Antibody business |
| Zdroj: | Journal of Clinical Virology. 25:217-221 |
| ISSN: | 1386-6532 |
| Popis: | Background: The etiology of chronic urticaria is undefined, but the potential role of infectious agents as one triggering factor has been suggested. The appearance of chronic urticaria in a 16-year old male after a history of a recent parvovirus B19 (B19) infection led us to investigate the association between B19 and chronic urticaria. Objectives: To investigate whether parvovirus B19 (B19) has a role in chronic urticaria. Study design: We amplified B19 DNA from skin biopsy samples of 36 adult chronic urticaria patients as well as of 22 healthy controls using two sets of separate primers and probe. Circulating IgG and IgM antibodies to B19 were measured from 27 patients and from all controls. Results: B19 DNA was detected in 18 (50%) skin biopsy samples of 36 patients with chronic urticaria. Unexpectedly, also 14 (64%) skin biopsy samples from 22 healthy controls harbored B19 DNA. All 32 persons with positive B19 PCR findings had circulating IgG-class antibodies to B19 major structural protein VP2, but no IgM antibodies. Conclusion: Our results show that B19 DNA commonly exists in human skin. Therefore, the association between B19 infection and chronic urticaria remains uncertain. However, these findings raise the question whether the skin may constitute a reservoir for B19. |
| Databáze: | OpenAIRE |
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