Intestinal lymphoma in dogs: 84 cases (1997-2012)
| Autor: | Naoko Sogame, Rebecca E. Risbon, Kristine Burgess |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Vincristine Cyclophosphamide Lymphoma 040301 veterinary sciences Peritonitis Anorexia Gastroenterology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols Intestinal Neoplasms medicine Animals Clinical significance Dog Diseases Survival analysis Retrospective Studies Univariate analysis General Veterinary business.industry Records 04 agricultural and veterinary sciences medicine.disease Survival Analysis United States 030220 oncology & carcinogenesis Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of the American Veterinary Medical Association. 252(4) |
| ISSN: | 1943-569X |
| Popis: | OBJECTIVE To describe signalment, clinicopathologic features, and outcomes of dogs with confirmed primary intestinal lymphoma and assess factors associated with survival times in these patients. DESIGN Retrospective case series. ANIMALS 84 client-owned dogs. PROCEDURES Medical records from 7 veterinary institutions were retrospectively reviewed to identify dogs with primary intestinal lymphoma. Data collected included signalment, clinical signs, anatomic location of tumors, diagnostic procedures, treatment, outcome, and dates of diagnosis and death. RESULTS Overall median survival time (MST) was 62 days (range, 1 to 537 days). Factors associated with shorter survival time on univariate analysis included anorexia or septic peritonitis at the time of diagnosis and tumor location (intestinal tract only, intestinal tract and abdominal lymph nodes, or intestinal tract and extraintestinal organs). The most commonly noted changes in the intestinal tract were altered wall thickening with loss of layering (41 dogs) and presence of ≥ 1 discrete mass (24 dogs). Protocols based on cyclophosphamide, doxorubicin, vincristine, and prednisone with or without l-asparaginase (48 dogs) or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (14 dogs) were most commonly used as first-line treatment; the MSTs of dogs receiving these treatments (60 and 144 days, respectively) did not differ significantly. CONCLUSIONS AND CLINICAL RELEVANCE The MST of dogs with primary intestinal lymphoma was poor, regardless of first-line treatment used. Anorexia and septic peritonitis were associated with poor prognosis. |
| Databáze: | OpenAIRE |
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