Cyclooxygenase-2 and B-cell lymphoma-2 expression in cystitis glandularis and primary vesicle adenocarcinoma
| Autor: | Rui Feng, Xiaobing Ju, Dan Wu, Guangcheng Ge, Bin Shen, Xing Wang, Junrong Li, Zhongxing Li, Yan Cui |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Urology Adenocarcinoma Cystitis medicine Biomarkers Tumor Humans Bcl-2 Cyclooxygenase-2 B-cell lymphoma Retrospective Studies Urinary bladder biology business.industry Vesicle General Medicine Chronic Cystitis medicine.disease medicine.anatomical_structure Reproductive Medicine Proto-Oncogene Proteins c-bcl-2 Urinary Bladder Neoplasms Cyclooxygenase 2 biology.protein Female Cyclooxygenase business Premalignant lesion Precancerous Conditions Cystitis glandularis Research Article |
| Zdroj: | BMC Urology |
| ISSN: | 1471-2490 |
| Popis: | Background Although cystitis glandularis (CG) is a common benign urinary bladder epithelial abnormality, it remains unclear whether CG is a premalignant lesion. Cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) overexpression has recently been reported as a potential tumor initiator or promoter. We evaluated and compared COX-2 and Bcl-2 expression in CG, chronic cystitis (CC), and primary vesicle adenocarcinoma (ADC) tissues. Methods We conducted a retrospective study to investigate COX-2 and Bcl-2 levels in CG and ADC. We obtained tissue samples from 75 patients (including 11 cases of CC, 30 typical cases of CG (CGTP), 30 cases of intestinal CG (CGIT), and 4 cases of ADC) between 1989 and 2009 from the Surgical Pathology Archives of the No. 2 People’s Hospital of Zhenjiang, affiliated with Jiangsu University. COX-2 and Bcl-2 immunohistochemical staining was performed on all tissues. Nine normal bladder epithelial specimens were evaluated as control samples. Correlations between COX-2 and Bcl-2 expression in CG were also analyzed. Results COX-2 and Bcl-2 expression was higher in the ADC group compared to other groups (p r = 0.648, p = 0.000). Conclusion COX-2 and Bcl-2 overexpression in the CG group suggests that CG, particularly the intestinal type, may be a premalignant lesion that converts into a tumor in the presence of carcinogens. |
| Databáze: | OpenAIRE |
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