Diagnostic Performance of Electromagnetic Navigation Bronchoscopy-Guided Biopsy for Lung Nodules in the Era of Molecular Testing
Autor: | Chang-Min Choi, Wonjun Ji, Hee Sang Hwang, Se Jin Jang, Ju Hyun Oh, Mi Young Kim, Seulgi Kim, Sang Young Oh |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
safety
Target lesion Medicine (General) medicine.medical_specialty Percutaneous Clinical Biochemistry lung nodule Article R5-920 electromagnetic navigation bronchoscopy Biopsy medicine Anaplastic lymphoma kinase Transthoracic needle biopsy Lung accuracy diagnostic yield medicine.diagnostic_test business.industry medicine.disease medicine.anatomical_structure Pneumothorax Radiology business Electromagnetic navigation bronchoscopy |
Zdroj: | Diagnostics; Volume 11; Issue 8; Pages: 1432 Diagnostics Diagnostics, Vol 11, Iss 1432, p 1432 (2021) |
ISSN: | 2075-4418 |
DOI: | 10.3390/diagnostics11081432 |
Popis: | Electromagnetic navigation bronchoscopy (ENB) is an emerging technique used to evaluate peripheral lung lesions. The aim of this study was to determine the diagnostic yield, safety profile, and adequacy of specimens obtained using ENB for molecular testing. This single-center, prospective pilot study recruited patients with peripheral pulmonary nodules that were not suitable for biopsy via percutaneous transthoracic needle biopsy methods. The possibility of molecular testing, including epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and programmed death ligand 1 (PD-L1), was identified with non-small cell lung cancer (NSCLC) tissue obtained using ENB. ENB-guided biopsy was performed on 30 pulmonary nodules in 30 patients. ENB-guided biopsy was successfully performed in 96.6% (29/30) of cases, but one case failed to approach the target lesion. The diagnostic accuracy of ENB-guided biopsy was 68.0% (17/25). Biopsy-related pneumothorax occurred in one patient and there was no major bleeding or deaths related to the procedure. Among 13 patients diagnosed with NSCLC, molecular testing was successfully performed in 92.3% (12/13). ENB-guided biopsy demonstrated acceptable accuracy and excellent sample adequacy, with a high possibility of achieving molecular testing and a good safety profile to evaluate peripheral pulmonary nodules, even when the percutaneous approach was difficult and/or dangerous. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |