Chronic red blood cell exchange to prevent clinical complications in sickle cell disease
| Autor: | Giovanna Oriella Manenti, Francesco Costantino, Francesco Bennardello, Salvatore Calabrese, Pietro Bonomo, Giovanni Garozzo, Carmelo Fidone, Roberto Distefano, Sergio Cabibbo, Agostino Antolino, Simone Travali, Vincenzo Licitra |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Erythrocyte transfusion medicine.medical_specialty Iron Overload Adolescent Anemia Cell Ferritin levels Blood Donors Disease Anemia Sickle Cell Gastroenterology Internal medicine medicine Secondary Prevention Humans In patient Child Retrospective Studies business.industry Retrospective cohort study Hematology Middle Aged medicine.disease Red blood cell medicine.anatomical_structure Immunology Female business Erythrocyte Transfusion |
| Zdroj: | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 32(3) |
| ISSN: | 1473-0502 |
| Popis: | We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of sickle cell disease, and if done automatically, reduced iron overload. Ferritin levels also decreased in patients treated with automatic red blood cell exchange. Furthermore, using Single Donor Red Blood Cell units (SDRC) we reduced the potential exposure to transfusion transmitted infectious diseases (TTI). |
| Databáze: | OpenAIRE |
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