Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition

Autor: Xu Chen, Jie Liu, Ange Lin, Jiawei Liu, Yanhui Zhou, Xufeng Zhu, Yanan Liu, Xiuying Qin
Rok vydání: 2019
Předmět:
Male
Methicillin-Resistant Staphylococcus aureus
Cell Membrane Permeability
medicine.drug_class
Antibiotics
General Physics and Astronomy
chemistry.chemical_element
Biocompatible Materials
Microbial Sensitivity Tests
02 engineering and technology
010402 general chemistry
medicine.disease_cause
01 natural sciences
Fluorescence
Microbiology
Selenium
Immune system
Biomimetics
In vivo
Drug Resistance
Multiple
Bacterial
Escherichia coli
medicine
Animals
Gelatinase
General Materials Science
Immune Evasion
Mice
Inbred BALB C
biology
Macrophages
Erythrocyte Membrane
General Engineering
Bacterial Infections
021001 nanoscience & nanotechnology
biology.organism_classification
Endocytosis
Anti-Bacterial Agents
0104 chemical sciences
Multiple drug resistance
Disease Models
Animal
Drug Liberation
chemistry
Staphylococcus aureus
Gelatin
Nanoparticles
Cattle
Reactive Oxygen Species
0210 nano-technology
Bacteria
Zdroj: ACS Nano. 13:13965-13984
ISSN: 1936-086X
1936-0851
DOI: 10.1021/acsnano.9b05766
Popis: Multidrug-resistant (MDR) bacterial infections are a severe threat to public health owing to their high risk of fatality. Noticeably, the premature degradation and undeveloped imaging ability of antibiotics still remain challenging. Herein, a selenium nanosystem in response to a bacteria-infected microenvironment is proposed as an antibiotic substitute to detect and inhibit methicillin-resistant Staphylococcus aureus (MRSA) with a combined strategy. Using natural red blood cell membrane (RBCM) and bacteria-responsive gelatin nanoparticles (GNPs), the Ru-Se@GNP-RBCM nanosystem was constructed for effective delivery of Ru-complex-modified selenium nanoparticles (Ru-Se NPs). Taking advantage of natural RBCM, the immune system clearance was reduced and exotoxins were neutralized efficiently. GNPs could be degraded by gelatinase in pathogen-infected areas in situ; therefore, Ru-Se NPs were released to destroy the bacteria cells. Ru-Se NPs with intense fluorescence imaging capability could accurately monitor the infection treatment process. Moreover, excellent in vivo bacteria elimination and a facilitated wound healing process were confirmed by two kinds of MRSA-infected mice models. Overall, the above advantages proved that the prepared nanosystem is a promising antibiotic alternative to combat the ever-threatening multidrug-resistant bacteria.
Databáze: OpenAIRE
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