Neural Function Before and After Mindfulness-Based Cognitive Therapy in Anxious Adolescents at Risk for Developing Bipolar Disorder
| Autor: | Christina M. Luberto, Lauren Stahl, Jeffrey R. Strawn, Wade Weber, Sian Cotton, Richard W. Sears, James C. Eliassen, Melissa P. DelBello, L. Rodrigo Patino |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Mindfulness Adolescent medicine.medical_treatment Neuropsychological Tests Audiology 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Pharmacology (medical) Longitudinal Studies Bipolar disorder Child Psychiatry Mindfulness-based cognitive therapy Cognitive Behavioral Therapy medicine.diagnostic_test Separation anxiety disorder Brain Original Articles medicine.disease Anxiety Disorders Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Treatment Outcome Pediatrics Perinatology and Child Health Cognitive therapy Anxiety Female medicine.symptom Functional magnetic resonance imaging Psychology Insula 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child and Adolescent Psychopharmacology. 26:372-379 |
| ISSN: | 1557-8992 1044-5463 |
| Popis: | We sought to evaluate the neurophysiology of mindfulness-based cognitive therapy for children (MBCT-C) in youth with generalized, social, and/or separation anxiety disorder who were at risk for developing bipolar disorder.Nine youth (mean age: 13 ± 2 years) with a generalized, social, and/or separation anxiety disorder and a parent with bipolar disorder completed functional magnetic resonance imaging (fMRI) while performing a continuous processing task with emotional and neutral distractors (CPT-END) prior to and following 12 weeks of MBCT-C.MBCT-C was associated with increases in activation of the bilateral insula, lentiform nucleus, and thalamus, as well as the left anterior cingulate while viewing emotional stimuli during the CPT-END, and decreases in anxiety were correlated with change in activation in the bilateral insula and anterior cingulate during the viewing of emotional stimuli (p 0.05, uncorrected; p 0.005 corrected; cluster size, 37 voxels).MBCT-C treatment in anxious youth with a familial history of bipolar disorder is associated with increased activation of brain structures that subserve interoception and the processing of internal stimuli-functions that are ostensibly improved by this treatment. |
| Databáze: | OpenAIRE |
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