Yield of endoscopic ultrasound-guided fine needle aspiration and endoscopic retrograde cholangiopancreatography for solid pancreatic neoplasms
| Autor: | Lotfy Hamed Abo Dahab, Takeshi Ogura, Daisuke Masuda, Usama M. Abdelaal, Kazuhide Higuchi, Akira Imoto, Eman A. Sabet, Mohamed M. Malak |
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| Rok vydání: | 2015 |
| Předmět: |
Endoscopic ultrasound
Male medicine.medical_specialty Malignancy Sensitivity and Specificity Group B 03 medical and health sciences 0302 clinical medicine Cytology Pancreatic mass Medicine Humans Endoscopic Ultrasound-Guided Fine Needle Aspiration Pancreas Aged Retrospective Studies Cholangiopancreatography Endoscopic Retrograde Endoscopic retrograde cholangiopancreatography medicine.diagnostic_test business.industry Carcinoma Gastroenterology Middle Aged medicine.disease digestive system diseases Pancreatic Neoplasms surgical procedures operative Fine-needle aspiration 030220 oncology & carcinogenesis Pancreas Head 030211 gastroenterology & hepatology Female Radiology business |
| Zdroj: | Scandinavian journal of gastroenterology. 51(3) |
| ISSN: | 1502-7708 |
| Popis: | Both endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and endoscopic retrograde cholangiopancreatography (ERCP) cytology may provide tissue diagnoses in solid pancreatic neoplasms. However, there are scant data comparing these two methods. This study aims at retrospectively comparing EUS-FNA and ERCP tissue sampling and ability of cytopathological diagnosis in solid pancreatic neoplasms and to determine usefulness and adverse events of combining both procedures.Two hundred and thirty four patients suspected to have solid pancreatic mass on abdominal ultrasound and/or computed tomography (CT) were enrolled. EUS-FNA (group A), ERCP cytology (group B) and combined procedures (Group C) performed in 105, 91 and 38 cases, respectively.Sensitivity, specificity and accuracy were 98.9%, 93.3% and 98.1% for group A, and 72.1%, 60% and 71.4% for group B. Those for group C were all 100%. Sensitivity for malignancy in the pancreas head was 100% for group A and 82.4% for group B, and in the pancreas body and tail, 97.6% for group A and 57.1% for group B. EUS-FNA was more sensitive than ERCP cytology in diagnosing malignant pancreatic neoplasms 21-30 mm in size (p = 0.0068), 31-40 mm (p = 0.028) and ≥ 41 mm (p0.0001). Sensitivity for pancreatic malignancy with group C was 100% regardless of mass location or size. Adverse events were 1.9%, 6.6% and 2.6% following EUS-FNA, ERCP and combined procedures, respectively.EUS-FNA is superior to ERCP cytology for diagnosis of solid pancreatic neoplasms. Although combination of both procedures provide efficient tissue diagnosis and with a minimal adverse events rate, a prospective study including larger number of patients is required. |
| Databáze: | OpenAIRE |
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