Plasma 25-Hydroxyvitamin D and Its Genetic Determinants in Relation to Incident Myocardial Infarction and Stroke in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany Study
| Autor: | Cornelia Weikert, Frank Hirche, Rudolf Kaaks, Tilman Kühn, Birgit Teucher, Verena Katzke, Jutta Dierkes, Heiner Boeing, Brian Buijsse, Gabriele I. Stangl |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Myocardial Infarction lcsh:Medicine Polymorphism Single Nucleotide Gastroenterology White People Risk Factors Tandem Mass Spectrometry Germany Internal medicine medicine Vitamin D and neurology Humans Prospective Studies cardiovascular diseases Myocardial infarction Vitamin D lcsh:Science Prospective cohort study Stroke Aged Multidisciplinary business.industry Incidence lcsh:R Confounding Hazard ratio Middle Aged medicine.disease Confidence interval Surgery European Prospective Investigation into Cancer and Nutrition Steroid Hydroxylases Female lcsh:Q Oxidoreductases business Genome-Wide Association Study Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 7, p e69080 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Circulating 25-hydroxyvitamin D (25(OH)D) has been associated with cardiovascular disease (CVD) risk in observational studies. Also, SNPs to explain variation in 25(OH)D have been identified by genome-wide association studies. Detection of direct associations between SNPs that significantly affect 25(OH)D and CVD risk would indicate a causal role of vitamin D, as reverse causation could be excluded and confounding could be better controlled. Thus, a combined analysis of candidate SNPs in relation to circulating 25(OH)D and CVD risk was carried out. A case-cohort study within the EPIC-Germany study was conducted comprising a randomly drawn subcohort of 2,132 subjects (57.9% women, mean age: 50.6 years) and incident cases of myocardial infarction (n=559) and stroke (n=471) that occurred during a mean follow-up duration of 7.6 years. 25(OH)D concentrations were measured by LC-MS/MS in baseline plasma samples. Additionally, eight candidate SNPs were assayed. Associations between 25(OH)D, SNPs and the risks of myocardial infarction and stroke were assessed by multivariable regression analyses. Mean 25(OH)D level was 47.2 nmol/L in the subcohort. Four SNPs were associated with 25(OH)D (p |
| Databáze: | OpenAIRE |
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