VASCULAR RESPONSES TO REN-293 (2-amino-3[3, 5-dihydroxyphenyl]-1-propanol hydrochloride)-A NEW SYMPATHOMIMETIC AGENT

Autor:	DB Frewin, BR Frost
Rok vydání:	1981
Předmět:	Ephedrine Male Tail Hydrochloride Clinical Biochemistry Immunology Tyramine Arteries Cell Biology General Medicine Medicinal chemistry Muscle Smooth Vascular Rats Propanolamines Norepinephrine chemistry.chemical_compound 1-Propanol chemistry Vasoconstriction Animals Etilefrine Sympathomimetics
Zdroj:	Australian Journal of Experimental Biology and Medical Science. 59:179-182
ISSN:	0004-945X
DOI:	10.1038/icb.1981.13
Popis:	In this study the effects of REN-293 have been examined on the rat tail artery "in situ'. It was found that the drug was totally dependent on the sympathetic nerves for its vasoconstrictor action. This action was blocked by phentolamine and attenuated by pre-treatment of the vessel with tyramine. When a comparative study of the vasoconstrictor effects of several sympathomimetics was performed, it was found that REN-293 was more potent than tyramine and ephedrine, but less so than etilefrine. It would appear that REN-293 is of interest as a pharmacological tool for examining sympathetic nerve function, but its usefulness in the therapy of orthostatic hypotension is likely to be limited, due to the very indirect nature of its sympathomimetic action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc6f39c200413145e1cac27d2dfd79 https://doi.org/10.1038/icb.1981.13 Zobrazit plný text záznamu Plný text