[Pathogenetic and Prognostic Role of Growth Factors in the Development of Chronic Heart Failure]
| Autor: | S N Shilov, M G Pustovetova, E V Grakova, A V Efremova, A T Teplyakov, E N Berezikova, Yu. Yu. Torim, I D Safronov, A. V. Andriyanova, A A Popova |
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| Předmět: |
0301 basic medicine
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Platelet-derived growth factor Heart disease Basic fibroblast growth factor 030204 cardiovascular system & hematology Gastroenterology Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum Internal medicine Medicine Humans cardiovascular diseases Heart Failure Platelet-Derived Growth Factor business.industry medicine.disease Prognosis Vascular endothelial growth factor Vascular endothelial growth factor A 030104 developmental biology chemistry Heart failure Cardiology and Cardiovascular Medicine business |
| Zdroj: | Europe PubMed Central |
| Popis: | Aim To study the role of growth factors ((vascular endothelial growth factor (VEGF), platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (FGF-basic)) in the development and progression of chronic heart failure (CHF) in patients with ishcemic heart disease (IHD). Materials and methods We included in this study 94 patients with CHF. The control group comprised 32 persons. Blood serum levels of growth factors were determined at baseline and after 12 months of observation by enzyme-linked immunosorbent assay. Results VEGF, PDGF-AB and FGF-basic play an important role in the pathogenesis and progression of heart failure in patients with IHD, determining the increased risk of adverse cardiovascular events in this pathology. Serum activity of growth factors characterizes the severity and course of CHF: with disease progression levels of VEGF and FGF-basic decrease and PDGF-AB concentration increases. Initial low level of VEGF expression regardless of the sex of the patient's sex, significantly low level of FGF-basic and significantly high PDGF-AB in men characterizes unfavorable course of CHF. Conclusion A correlation has been established between blood serum levels of VEGF, PDGF-AB and FGF-basic and severity and course of CHF. |
| Databáze: | OpenAIRE |
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