Alteration in synaptic junction proteins following traumatic brain injury
| Autor: | Lucia Merlo, Domenico La Torre, Alfredo Conti, Antonino Germanò, Filippo Flavio Angileri, Antonella Saija, Francesco Cimino, Salvatore Cardali |
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| Přispěvatelé: | Merlo L, Cimino F, Angileri FF, La Torre D, Conti A, Cardali SM, Saija A, Germanò A. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Traumatic brain injury
traumatic brain injury neuroplasticity Protein database Nerve Tissue Proteins Synaptic junction medicine.disease Neuromodulation (medicine) Synapse Synaptic fatigue nervous system Brain Injuries Synapses Neuroplasticity Synaptic plasticity medicine synaptic junction disfunction Animals Humans Neurology (clinical) Psychology Neuroscience |
| Popis: | Extensive research and scientific efforts have been focused on the elucidation of the pathobiology of cellular and axonal damage following traumatic brain injury (TBI). Conversely, few studies have specifically addressed the issue of synaptic dysfunction. Synaptic junction proteins may be involved in post-TBI alterations, leading to synaptic loss or disrupted plasticity. A Synapse Protein Database on synapse ontology identified 109 domains implicated in synaptic activities and over 5000 proteins, but few of these demonstrated to play a role in the synaptic dysfunction after TBI. These proteins are involved in neuroplasticity and neuromodulation and, most importantly, may be used as novel neuronal markers of TBI for specific intervention. |
| Databáze: | OpenAIRE |
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