Current insights in the pathogenesis of scleritis
| Autor: | Robert M. Verdijk, J. A. M. van Laar, Johannes R. Vingerling, J.C. Ten Berge, Aniki Rothova, D.P.C. Vergouwen, Marco W.J. Schreurs |
|---|---|
| Přispěvatelé: | Immunology, Ophthalmology, Pathology, Internal Medicine |
| Rok vydání: | 2020 |
| Předmět: |
Diagnostic Imaging
medicine.medical_specialty genetic structures Inflammation Autoimmunity Disease medicine.disease_cause Keratitis Pathogenesis Cellular and Molecular Neuroscience medicine Humans Blindness business.industry medicine.disease Dermatology eye diseases Sensory Systems Matrix Metalloproteinases Ophthalmology medicine.symptom business Scleritis Uveitis Sclera |
| Zdroj: | Experimental Eye Research, 197:108078. Academic Press |
| ISSN: | 1096-0007 0014-4835 |
| Popis: | Scleritis is a sight-threatening inflammation characterized by severe pain and redness of the eye. It can cause blindness by severe complications like scleral and corneal necrosis, keratitis, and uveitis. The pathogenesis of scleritis is largely unknown due to a combination of the rarity of the disease, the little available human tissue-based research material, and the lack of animal models. The immune system is assumed to play a crucial role in the pathogenesis of scleritis. Multiple clues indicate probable antigenic stimuli in scleritis, and the involvement of matrix metalloproteinases in the destruction of scleral tissue. In this article we review the current insights into the pathogenesis of scleritis, and we suggest new hypotheses by implementing knowledge of systemic autoimmune disease pathogenesis. Understanding the pathogenesis of scleritis is crucial to improve the clinical management, as well as to find novel treatment modalities. |
| Databáze: | OpenAIRE |
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