Combination pharmacotherapy in children and adolescents with bipolar disorder
| Autor: | Judith H Hume, Robert A. Kowatch, Michelle Kromelis, Gopalan Sethuraman, Warren A. Weinberg |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Bipolar Disorder Combination therapy Adolescent medicine.drug_class medicine.medical_treatment Atypical antipsychotic Lithium Antipsychotic Agent Antimanic Agents mental disorders medicine Humans Bipolar disorder Prospective Studies Psychiatry Child Bupropion Biological Psychiatry Valproic Acid Mood stabilizer medicine.disease Risperidone Antidepressive Agents Stimulant Mood Carbamazepine Attention Deficit Disorder with Hyperactivity Methylphenidate Antidepressant Central Nervous System Stimulants Drug Therapy Combination Female Psychology Selective Serotonin Reuptake Inhibitors Antipsychotic Agents |
| Zdroj: | Biological psychiatry. 53(11) |
| ISSN: | 0006-3223 |
| Popis: | Background The purpose of this study was to develop prospective data on the effectiveness of combination pharmacotherapy of children and adolescents with bipolar disorder during a 6-month period of prospective, semi-naturalistic treatment. Methods Thirty-five subjects, with a mean age of 11 years, were treated in the extension phase of this study after having received 6–8 weeks of acute treatment with a single mood stabilizer. The extension phase of this study lasted for another 16 weeks, for a total of 24 weeks of prospective treatment. During this study phase, subjects were openly treated, and they could have their acute-phase mood stabilizer switched or augmented with another mood stabilizer, a stimulant, an antidepressant agent, or antipsychotic agent, if they were assessed to be a nonresponder to monotherapy with their initial mood stabilizer. Results During the extension phase of treatment, 20 of 35 subjects (58%) required treatment with one or two mood stabilizers and either a stimulant, an atypical antipsychotic agent, or an antidepressant agent. The response rate to combination therapy was very good, with 80% of subjects treated responding to combination therapy with two mood stabilizers after not responding to monotherapy with a mood stabilizer. Conclusions This study suggests that children and adolescents with bipolar disorder are similar to adults with bipolar disorder, who also frequently require combination therapy. |
| Databáze: | OpenAIRE |
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