New naphthoquinone derivatives against glioma cells
| Autor: | Armando Gennaro, Giovanni Ribaudo, Raffaele Pezzani, Valeria Pavan, Carla Mucignat-Caretta, Riccardo Pasquale, Marco Crisma, Marco Redaelli, Giuseppe Zagotto, Abdirisak Ahmed Isse |
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| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Cell Survival Stereochemistry Antineoplastic Agents Naphtoquinones glioma 4-NAPHTHOQUINONE CYTO-TOXICITY METABOLISM CANCER MECHANISMS INDUCTION DAMAGE METABOLISM Crystallography X-Ray Electrochemistry Redox CYTO-TOXICITY MECHANISMS Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor 4-NAPHTHOQUINONE Glioma Drug Discovery Temozolomide medicine Humans Cell Proliferation DAMAGE Pharmacology Cell Death Dose-Response Relationship Drug Molecular Structure INDUCTION Organic Chemistry General Medicine medicine.disease CANCER Combinatorial chemistry Naphthoquinone chemistry Drug Screening Assays Antitumor Naphthoquinones |
| Zdroj: | European journal of medicinal chemistry 96 (2015): 458–466. doi:10.1016/j.ejmech.2015.04.039 info:cnr-pdr/source/autori:Redaelli, Marco; Mucignat-Caretta, Carla; Isse, Abdirisak Ahmed; Gennaro, Armando; Pezzani, Raffaele; Pasquale, Riccardo; Pavan, Valeria; Crisma, Marco; Ribaudo, Giovanni; Zagotto, Giuseppe/titolo:New naphthoquinone derivatives against glioma cells/doi:10.1016%2Fj.ejmech.2015.04.039/rivista:European journal of medicinal chemistry/anno:2015/pagina_da:458/pagina_a:466/intervallo_pagine:458–466/volume:96 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2015.04.039 |
| Popis: | This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided. (C) 2015 Elsevier Masson SAS. All rights reserved. |
| Databáze: | OpenAIRE |
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