CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial
| Autor: | Emily A. Holmes, Sue Healy, Julie O’Connor, Annie Hendry, Penney Lewis, Sian Roberts, Rossela Roberts, Jessica L Roberts, Clare Wilkinson, Marlise Poolman, Betty Foster, Paul Perkins, Zoe Hoare, Annmarie Nelson, Liz Reymond, Julia Hiscock, Anthony Byrne, Rosalynde P Johnstone, Bee Wee, Stella Wright, Dyfrig A. Hughes |
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| Rok vydání: | 2018 |
| Předmět: |
Health Knowledge
Attitudes Practice Palliative care Time Factors Medicine (miscellaneous) Pilot Projects Education Nonprofessional law.invention Study Protocol 0302 clinical medicine Randomized controlled trial law Hypnotics and Sedatives Multicenter Studies as Topic Pharmacology (medical) 030212 general & internal medicine Randomized Controlled Trials as Topic lcsh:R5-920 Care of the dying Analgesics Terminal Care Palliative Care Health technology Home Care Services Substance abuse Treatment Outcome End-of-life care Caregivers lcsh:Medicine (General) Risk assessment medicine.medical_specialty Attitude to Death Injections Subcutaneous education Randomised pilot trial 03 medical and health sciences Intervention (counseling) medicine Humans business.industry medicine.disease United Kingdom Family medicine Antiemetics Feasibility Studies Carer administration business human activities Delivery of Health Care 030217 neurology & neurosurgery Symptom control Qualitative research |
| Zdroj: | TRIALS Poolman, M, Roberts, J, Byrne, A, Perkins, P, Hoare, Z, Nelson, A, Hiscock, J, Hughes, D, Foster, B, O’connor, J, Reymond, L, Healy, S, Roberts, R, Wee, B, Lewis, P, Johnstone, R, Roberts, S, Holmes, E, Wright, S, Hendry, A & Wilkinson, C 2019, ' CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD) : study protocol for a UK-based open randomised pilot trial ', Trials, vol. 20, no. 1, 105 . https://doi.org/10.1186/s13063-019-3179-9 Trials Trials, Vol 20, Iss 1, Pp 1-16 (2019) |
| ISSN: | 1121-1024 |
| DOI: | 10.21203/rs.2.122/v1 |
| Popis: | Background: Whilst the majority of seriously ill people wish to die at home, only half achieve this. The likelihood of someone dying at home often depends on the availability of able and willing lay carers to support them. Dying people are usually unable to take oral medication. When top-up symptom relief medication is required, a clinician travels to the home to administer injectable medication, with attendant delays. The administration of subcutaneous injections by lay carers, though not widespread practice in the UK, has proven key in achieving home deaths in other countries. Our aim is to determine if carer-administration of as-needed subcutaneous medication for four frequent breakthrough symptoms (pain, nausea, restlessness and noisy breathing) in home-based dying patients is feasible and acceptable in the UK. Methods: The paper describes a randomised pilot trial across three UK sites, with an embedded qualitative study. Dyads of adult patients/carers are eligible, where patients are in the last weeks of life, wish to die at home, and lay carers who are willing to be trained to give subcutaneous medication. Dyads who do not meet strict risk assessment criteria (including known history of substance abuse or carer ability to be trained to competency) will not be approached. Carers in the intervention arm will receive a manualised training package delivered by their local nursing team. Dyads in the control arm will receive usual care. The main outcomes of interest are feasibility, acceptability, recruitment rates, attrition and selection of the most appropriate outcome measures. Interviews with carers and healthcare professionals will explore attitudes to, experiences of and preferences for giving subcutaneous medication and experience of trial processes. The study has obtained full ethical approval. Discussion: This study will rehearse the procedures and logistics which will be undertaken in a future definitive randomised controlled trial, and will inform the design of such a study. Findings will illuminate methodological and ethical issues pertaining to researching last days of life care. The study is funded by the National Institute for Health Research (Health Technology Assessment [HTA] project 15/10/37). Trial registration: ISRCTN, ISRCTN 11211024. Assigned 27 September 2016, http://www.isrctn.com/ISRCTN11211024. Keywords: End-of-life care, Care of the dying, Palliative care, Symptom control, Carer administration, Randomised pilot trial |
| Databáze: | OpenAIRE |
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