Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient
| Autor: | Zoilo Pires de Camargo, Michel Reis Abdalla, Keila Cristina dos Santos, Anderson Messias Rodrigues, Ricardo Nilsson Sgarbieri, Mario León Silva-Vergara, Kennio Ferreira-Paim, Cristina Hueb Barata, Patricia Ferreira Silva |
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| Přispěvatelé: | Fed Univ Tricingulo Mineiro, Universidade Federal de São Paulo (UNIFESP) |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cellular immunity Pathology medicine.medical_specialty Antifungal Agents Itraconazole AIDS-Related Opportunistic Infections Eye Endophthalmitis Amphotericin B Antiretroviral Therapy Highly Active Virology medicine Humans Endocarditis Vision Ocular Sporotrichosis biology business.industry Sporothrix HIV Articles medicine.disease biology.organism_classification Hospitalization Transplantation Treatment Outcome Infectious Diseases Parasitology business Brazil medicine.drug |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. Sporothrix brasiliensis isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. the patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by S. brasiliensis. Fed Univ Tricingulo Mineiro, Hosp Clin, Infect & Parasit Dis Unit, Uberaba, MG, Brazil Universidade Federal de São Paulo, Microbiol Immunol & Parasitol Unit, São Paulo, Brazil Universidade Federal de São Paulo, Microbiol Immunol & Parasitol Unit, São Paulo, Brazil FAPEMIG: PQ1813/09 Web of Science |
| Databáze: | OpenAIRE |
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