Role of purines on hepatic ischemia-reperfusion lesions in rabbit
| Autor: | M O, Taha, M J, Simões, M V, Mendonça, F R C, Lugo, R, Carmo-Filho, J L, Lazarini, M Z, Bessa, T D, Marconi, K G, Magalhães, J H, Soares, I L S, Tersariol, H P, Monteiro, I S, Oliveira-Júnior, I, Oliveira, A, Jurkiewicz, A, Caricati-Neto |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Mitochondria Liver Lipid peroxidation chemistry.chemical_compound Adenosine Triphosphate Internal medicine medicine Animals Aspartate Aminotransferases Transplantation biology L-Lactate Dehydrogenase business.industry Liver Diseases Alanine Transaminase medicine.disease Adenosine Endocrinology chemistry Biochemistry Alanine transaminase Liver Apoptosis Purines Reperfusion Injury biology.protein Surgery Rabbits business Adenosine triphosphate Reperfusion injury medicine.drug |
| Zdroj: | Transplantation proceedings. 41(3) |
| ISSN: | 0041-1345 |
| Popis: | In this work, we evaluate the effects of adenosine 5' triphosphate (ATP) on hepatic lesions caused by ischemia/reperfusion (I/R) in liver rabbit. Rabbits were pretreated with ATP (15 mg/kg IV) or saline solution 0.9% (SS), before the hepatic I/R procedure. We evaluated the effects of ATP on hepatic injury before and after I/R. The warm hepatic I/R procedure caused profound acute liver injury, as indicated by elevated serum aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels, as well as a high apoptotic cell count. All these changes were attenuate by ATP treatment before the hepatic I/R procedure. These results suggested that ATP exerted protective effects on hepatic I/R lesions in the rabbit. This ATP effect may be related to improved energy metabolism during reperfusion in ischemic livers protecting against functional damage of cellular and subcellular membranes during lipid peroxidation. |
| Databáze: | OpenAIRE |
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