Glycosylation of Mouse DPP4 Plays a Role in Inhibiting Middle East Respiratory Syndrome Coronavirus Infection

Autor:	Trevor Scobey, Boyd Yount, Mark T. Heise, Adam S. Cockrell, Ralph S. Baric, Kayla M. Peck
Přispěvatelé:	Plazi
Rok vydání:	2015
Předmět:	Models Molecular Glycosylation Coronaviridae Coronaviruses Middle East respiratory syndrome coronavirus Dipeptidyl Peptidase 4 viruses Molecular Sequence Data Immunology Fluorescent Antibody Technique MERS (Disease) Biology medicine.disease_cause Microbiology virus-host Mice chemistry.chemical_compound Species Specificity pathogen-host Virology medicine Animals Model development biotic relations Amino Acid Sequence Viridae Receptor Peptide sequence Dipeptidyl peptidase-4 biotic associations corona viruses virus diseases covid pathogens Virus Internalization biotic interaction respiratory tract diseases Virus-Cell Interactions covid-19 chemistry FOS: Biological sciences Insect Science Middle East Respiratory Syndrome Coronavirus Coronavirus Infections Function (biology) CETAF-taskforce
Zdroj:	Journal of Virology
ISSN:	1098-5514 0022-538X
DOI:	10.1128/jvi.03445-14
Popis:	Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.
Databáze:	OpenAIRE
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