Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers
Autor: | Francesco Dionisi, Francesco Cellini, Giovanna Mantello, F. Navarria, Gabriella Macchia, Luciana Caravatta, R.M. Niespolo, Claudio Vecchi, Gian Carlo Mattiucci, Domenico Genovesi, Aldo Sainato, Vincenzo Fusco, Alessio G. Morganti, Vincenzo Picardi, Roberta Cianci, Vincenzo Valentini, Raffaella Basilico, N. Simoni, Antonino De Paoli, M.E. Rosetto, Consuelo Rosa, Alessandra Guido, Marco Lupattelli, Marta Di Nicola, Andrea Delli Pizzi |
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Přispěvatelé: | Caravatta, Luciana, Cellini, Francesco, Simoni, Nicola, Rosa, Consuelo, Niespolo, Rita Marina, Lupattelli, Marco, Picardi, Vincenzo, Macchia, Gabriella, Sainato, Aldo, Mantello, Giovanna, Dionisi, Francesco, Rosetto, Maria Elena, Fusco, Vincenzo, Navarria, Federico, De Paoli, Antonino, Guido, Alessandra, Vecchi, Claudio, Basilico, Raffaella, Cianci, Roberta, Delli Pizzi, Andrea, Di Nicola, Marta, Mattiucci, Gian Carlo, Valentini, Vincenzo, Morganti, Alessio Giuseppe, Genovesi, Domenico |
Rok vydání: | 2019 |
Předmět: |
Male
Aged Female Follow-Up Studies Gastrointestinal Neoplasms Humans Magnetic Resonance Imaging Pancreatic Neoplasms Prognosis Radiotherapy Planning Computer-Assisted Retrospective Studies Tomography X-Ray Computed Tumor Burden Observer Variation Radiotherapy Planning 030218 nuclear medicine & medical imaging 03 medical and health sciences Computer-Assisted 0302 clinical medicine MRI GTV pancreatic cancer Pancreatic tumor Pancreatic cancer medicine Radiology Nuclear Medicine and imaging Radiation treatment planning Tomography Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA Contouring medicine.diagnostic_test business.industry Soft tissue Magnetic resonance imaging Hematology General Medicine medicine.disease X-Ray Computed Gross tumor volume Oncology 030220 oncology & carcinogenesis business Nuclear medicine |
Zdroj: | Acta Oncologica. 58:439-447 |
ISSN: | 1651-226X 0284-186X |
Popis: | Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT).Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy.Thirty-one radiation oncologists from different Institutions submitted the delineated volumes. CT- and MRI-GTV mean volumes were 21.6 ± 9.0 cmDiagnostic MRI resulted in smaller GTV in borderline resectable case with a substantial agreement between observers, and was comparable to CT scan in interobserver variability, in both cases. The greater variability in the unresectable case underlines the critical issues related to the outlining when vascular structures are more involved. The integration of MRI with contrast-enhancement CT, thanks to its high definition of tumor relationship with neighboring vessels, could offer a greater accuracy of target delineation. |
Databáze: | OpenAIRE |
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