Magnetic resonance imaging (MRI) compared with computed tomography (CT) for interobserver agreement of gross tumor volume delineation in pancreatic cancer: a multi-institutional contouring study on behalf of the AIRO group for gastrointestinal cancers

Autor: Francesco Dionisi, Francesco Cellini, Giovanna Mantello, F. Navarria, Gabriella Macchia, Luciana Caravatta, R.M. Niespolo, Claudio Vecchi, Gian Carlo Mattiucci, Domenico Genovesi, Aldo Sainato, Vincenzo Fusco, Alessio G. Morganti, Vincenzo Picardi, Roberta Cianci, Vincenzo Valentini, Raffaella Basilico, N. Simoni, Antonino De Paoli, M.E. Rosetto, Consuelo Rosa, Alessandra Guido, Marco Lupattelli, Marta Di Nicola, Andrea Delli Pizzi
Přispěvatelé: Caravatta, Luciana, Cellini, Francesco, Simoni, Nicola, Rosa, Consuelo, Niespolo, Rita Marina, Lupattelli, Marco, Picardi, Vincenzo, Macchia, Gabriella, Sainato, Aldo, Mantello, Giovanna, Dionisi, Francesco, Rosetto, Maria Elena, Fusco, Vincenzo, Navarria, Federico, De Paoli, Antonino, Guido, Alessandra, Vecchi, Claudio, Basilico, Raffaella, Cianci, Roberta, Delli Pizzi, Andrea, Di Nicola, Marta, Mattiucci, Gian Carlo, Valentini, Vincenzo, Morganti, Alessio Giuseppe, Genovesi, Domenico
Rok vydání: 2019
Předmět:
Male
Aged
Female
Follow-Up Studies
Gastrointestinal Neoplasms
Humans
Magnetic Resonance Imaging
Pancreatic Neoplasms
Prognosis
Radiotherapy Planning
Computer-Assisted
Retrospective Studies
Tomography
X-Ray Computed
Tumor Burden
Observer Variation
Radiotherapy Planning
030218 nuclear medicine & medical imaging
03 medical and health sciences
Computer-Assisted
0302 clinical medicine
MRI GTV pancreatic cancer
Pancreatic tumor
Pancreatic cancer
medicine
Radiology
Nuclear Medicine and imaging
Radiation treatment planning
Tomography
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Contouring
medicine.diagnostic_test
business.industry
Soft tissue
Magnetic resonance imaging
Hematology
General Medicine
medicine.disease
X-Ray Computed
Gross tumor volume
Oncology
030220 oncology & carcinogenesis
business
Nuclear medicine
Zdroj: Acta Oncologica. 58:439-447
ISSN: 1651-226X
0284-186X
Popis: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve the accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed to evaluate the impact of MRI on inter-observer agreement in gross tumor volume (GTV) and duodenum delineation for pancreatic cancer compared with computer tomography (CT).Two clinical cases of borderline resectable (Case 1) and unresectable (Case 2) pancreatic cancer were selected. In two sequential steps, diagnostic contrast-enhanced CT scan and MRI sequences were sent to the participating centers. CT-GTVs were contoured while blinded to MRI data sets. DICE index was used to evaluate the spatial overlap accuracy.Thirty-one radiation oncologists from different Institutions submitted the delineated volumes. CT- and MRI-GTV mean volumes were 21.6 ± 9.0 cmDiagnostic MRI resulted in smaller GTV in borderline resectable case with a substantial agreement between observers, and was comparable to CT scan in interobserver variability, in both cases. The greater variability in the unresectable case underlines the critical issues related to the outlining when vascular structures are more involved. The integration of MRI with contrast-enhancement CT, thanks to its high definition of tumor relationship with neighboring vessels, could offer a greater accuracy of target delineation.
Databáze: OpenAIRE
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