Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes
| Autor: | Nihat Polat, Nigar Vardi, Tevfik Oğurel, Serkan Ozen, Hakan Parlakpinar, Murat Atabey Özer |
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| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı, Özer, Murat Atabey, Kırıkkale Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Proliferative vitreoretinopathy medicine.medical_specialty Rabbit Fundus (eye) Apocynin Eye Retina Sham group 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Animals Ophthalmoscopic examination business.industry Anti-Inflammatory Agents Non-Steroidal Vitreoretinopathy Proliferative Acetophenones medicine.disease eye diseases Ophthalmoscopy Vitreous Body Disease Models Animal Treatment Outcome chemistry Proliferative Vitreoretinopathy 030221 ophthalmology & optometry Indirect ophthalmoscope Rabbits sense organs business 030217 neurology & neurosurgery |
| Popis: | Parlakpinar, Hakan/0000-0001-9497-3468; OZER, MURAT ATABEY/0000-0003-1807-6911 WOS: 000401918500022 PubMed: 27495951 The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation. |
| Databáze: | OpenAIRE |
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