Direct asymmetric aldol reaction of hydroxyacetone promoted by chiral tertiary amines

Autor:	Joanna Paradowska, Maria Rogozińska, Jacek Mlynarski
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Aldol reaction chemistry organic chemicals Hydroxyacetone Organic Chemistry Drug Discovery polycyclic compounds Organic chemistry Aldol condensation Biochemistry Asymmetric induction Catalysis
Zdroj:	Tetrahedron Letters. 50:1639-1641
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.01.119
Popis:	The tertiary amine-catalyzed direct asymmetric aldol reaction of hydroxyacetone with a variety of aromatic aldehydes is developed. Using 5–10 mol % of quinidine as catalyst, the direct aldol condensation products were obtained in reasonable yields and with asymmetric induction (up to 47% ee). The present approach is extended to asymmetric organocatalytic strategies for the preparation of 1,2-diols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db05e1b9c9c9246d4d6177999535ad9 https://doi.org/10.1016/j.tetlet.2009.01.119 Zobrazit plný text záznamu Full Text from ScienceDirect