One pot solvent free synthesis and in vitro antitubercular screening of 3-Aracylphthalides against Mycobacterium tuberculosis
| Autor: | Varsha S. Honmore, Arun D. Natu, Madhusudan V. Paradkar, Rohan A. Limaye, Suwarna P. Gample, Dhiman Sarkar, Virendra B. Kumbhar, Rubia R. Chauhan |
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| Rok vydání: | 2012 |
| Předmět: |
Solvent free
biology Molecular Structure Organic Chemistry Clinical Biochemistry One-pot synthesis Antitubercular Agents Pharmaceutical Science Mycobacterium tuberculosis biology.organism_classification Biochemistry In vitro Benzaldehyde chemistry.chemical_compound Inhibitory Concentration 50 chemistry Yield (chemistry) Drug Discovery Solvents Molecular Medicine Organic chemistry Humans Molecular Biology Benzofurans |
| Zdroj: | Bioorganicmedicinal chemistry letters. 23(3) |
| ISSN: | 1464-3405 |
| Popis: | One pot synthesis of 3-Aracylphthalide was accomplished in good yield by reacting 2-carboxy benzaldehyde with various aromatic methyl ketones in presence of methane sulphonic acid. Various phthalides thus obtained were characterized with spectral techniques. These phthalides were subjected to in vitro antitubercular screening against Mycobacterium tuberculosis H37Ra (MTB) by using XRMA protocol. Among the phthalides screened, four exhibited half maximal inhibitory concentration (IC 50 ) in the range of 0.81–1.24 μg/ml thereby providing potential lead compounds for future drug discovery studies. |
| Databáze: | OpenAIRE |
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