The birth of yeast peroxisomes
| Autor: | Marten Veenhuis, Ida J. van der Klei, Wei Yuan |
|---|---|
| Přispěvatelé: | Molecular Cell Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Saccharomyces cerevisiae Proteins Mutant membrane contact sites Biology Peroxisome Endoplasmic Reticulum PEX10 Peroxins lipids 03 medical and health sciences Peroxisome-deficient mutant Yeasts Peroxisomes Animals Humans Protein Isoforms peroxisomal membrane protein Molecular Biology Peroxisomal targeting signal Gene Organelle Biogenesis Membrane Membrane Proteins Cell Biology Plants Yeast Cell biology Transport protein Protein Structure Tertiary Protein Transport 030104 developmental biology Eukaryotic Cells Biochemistry Membrane protein Gene Expression Regulation Signal Transduction |
| Zdroj: | Biochimica et biophysica acta, 1863(5):17661, 902-910 |
| ISSN: | 0006-3002 |
| DOI: | 10.1016/j.bbamcr.2015.09.008 |
| Popis: | This contribution describes the phenotypic differences of yeast peroxisome-deficient mutants (pex mutants). In some cases different phenotypes were reported for yeast mutants deleted in the same PEX gene. These differences are most likely related to the marker proteins and methods used to detect peroxisomal remnants. This is especially evident for pex3 and pex19 mutants, where the localization of receptor docking proteins (Pex13, Pex14) resulted in the identification of peroxisomal membrane remnants, which do not contain other peroxisomal membrane proteins, such as the ring proteins Pex2, Pex10 and Pex12. These structures in pex3 and pex19 cells are the template for peroxisome formation upon introduction of the missing gene. Taken together, these data suggest that in all yeast pex mutants analyzed so far peroxisomes are not formed de novo but use membrane remnant structures as a template for peroxisome formation upon reintroduction of the missing gene. The relevance of this model for peroxisomal membrane protein and lipid sorting to peroxisomes is discussed. This article is part of a Special Issue entitled: Peroxisomes. |
| Databáze: | OpenAIRE |
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