Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs
| Autor: | Zhengling Hao, Susan L. Schaefer, Jeffrey P. Little, Peter Muir, Molly A. Racette, Eric C. Hans, Nicola J. Volstad, Walter F. Block, Kenneth R. Waller, Susannah J. Sample, Jason A. Bleedorn |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences lcsh:Medicine Osteoarthritis 0403 veterinary science Cruciate ligament 03 medical and health sciences 0302 clinical medicine Dogs Synovitis Synovial Fluid Medicine Synovial fluid Animals Dog Diseases Anterior Cruciate Ligament lcsh:Science 030222 orthopedics Multidisciplinary medicine.diagnostic_test Tissue Scaffolds business.industry Platelet-Rich Plasma Anterior Cruciate Ligament Injuries Arthroscopy lcsh:R 04 agricultural and veterinary sciences medicine.disease Surgery medicine.anatomical_structure C-Reactive Protein Platelet-rich plasma Tibial-plateau-leveling osteotomy Ligament Female lcsh:Q business |
| Zdroj: | PLoS ONE, Vol 13, Iss 6, p e0197204 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Dogs are commonly affected with cruciate ligament rupture (CR) and associated osteoarthritis (OA), and frequently develop a second contralateral CR. Platelet rich plasma (PRP) is a component of whole blood that contains numerous growth factors, which in combination with a collagen scaffold may act to promote bioenhanced primary repair of ligament. This study tested the hypothesis that treatment of partial stable CR stifles with an intra-articular collagen scaffold and PRP would decrease the disease progression, synovitis and risk of complete CR over a 12-month study period. We conducted a prospective cohort study of 29 client-owned dogs with an unstable stifle due to complete CR and stable contralateral stifle with partial CR. All dogs were treated with tibial plateau leveling osteotomy (TPLO) on the unstable stifle and a single intra-articular application of PRP-collagen in the stable partial CR stifle. Dogs were evaluated at the time of diagnosis, and at 10-weeks and 12-months after treatment. We evaluated correlation between both development of complete CR and time to complete CR with diagnostic tests including bilateral stifle radiographs, 3.0 Tesla magnetic resonance (MR) imaging, and bilateral stifle arthroscopy. Additionally, histologic evaluation of synovial biopsies, C-reactive protein (CRP) concentrations in serum and synovial fluid, and synovial total nucleated cell count, were determined. Results indicated that a single application of PRP-collagen in partial CR stifles of client owned dogs is not an effective disease-modifying therapy for the prevention of progression to complete CR. Radiographic effusion, arthroscopic evaluation of cranial cruciate ligament (CrCL) damage, and MR assessment of ligament fiber tearing in partial CR stifles correlated with progression to complete CR over the 12-month follow-up period. We determined that the best predictive model for development of complete CR in PRP-collagen treated partial CR stifles included variables from multiple diagnostic modalities. |
| Databáze: | OpenAIRE |
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