The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
| Autor: | Liliana Tullo, Maria Laura Di Giorgio, Patrizia Morciano, Giovanni Cenci |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
DmATPCL ATP citrate lyase QH301-705.5 Gene Expression Golgi Apparatus Catalysis Inorganic Chemistry symbols.namesake Meiosis Organelle Melanogaster Animals Acroblast Drosophila Golgi stacks Lava lamp Spermatogenesis ATP Citrate (pro-S)-Lyase Spermatids Physical and Theoretical Chemistry Biology (General) Acrosome Molecular Biology QD1-999 Spectroscopy biology Chemistry Communication Organic Chemistry General Medicine Golgi apparatus biology.organism_classification acroblast spermatogenesis Computer Science Applications Cell biology symbols Spindle organization Cytokinesis |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5745, p 5745 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization, cytokinesis, and fusome assembly during male meiosis, mainly due to is activity on fatty acid biosynthesis. Here, we show that depletion of DmATPCL also affects the organization of acrosome and suggest a role for this enzyme in the assembly of Golgi-derived structures during Drosophila spermatogenesis. |
| Databáze: | OpenAIRE |
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