Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study
| Autor: | Eman M. Salem, Samar A. El Sheikh, Nour El Hoda S. Ismael, Suzan M. Talaat |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Immunohistochemistry Lynch Syndrome medicine.medical_specialty Pathology congenital hereditary and neonatal diseases and abnormalities Colorectal cancer lcsh:Medicine MLH1 03 medical and health sciences 0302 clinical medicine Basic Science Internal medicine medicine PMS2 neoplasms Microsatellite instability Mismatch repair proteins business.industry lcsh:R General Medicine medicine.disease Lynch syndrome digestive system diseases MSH6 030104 developmental biology MSH2 030220 oncology & carcinogenesis Medicine DNA mismatch repair business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences; Vol. 5 No. 1 (2017): Feb 15 (OAMJMS); 9-13 Open Access Macedonian Journal of Medical Sciences; Vol 5, No 1 (2017): Feb 15 (OAMJMS); 9-13 Open Access Macedonian Journal of Medical Sciences, Vol 5, Iss 1, Pp 9-13 (2017) |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite instability (MSI) is detected in about 15% of all colorectal cancers. CRC with MSI has particular characteristics such as improved survival rates and better prognosis. They also have a distinct sensitivity to the action of chemotherapy.AIM: The aim of the study was to detect microsatellite instability in a cohort of colorectal cancer Egyptian patients using the immunohistochemical expression of mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2).MATERIAL AND METHODS: Cases were divided into Microsatellite stable (MSS), Microsatellite unstable low (MSI-L) and Microsatellite unstable high (MSI-H). This Microsatellite stability status was correlated with different clinicopathological parameters.RESULTS: There was a statistically significant correlation between the age of cases, tumor site & grade and the microsatellite stability status. There was no statistically significant correlation between the gender of patients, tumor subtype, stage, mucoid change, necrosis, tumor borders, lymphocytic response, lymphovascular emboli and the microsatellite stability status.CONCLUSION: Testing for MSI should be done for all colorectal cancer patients, especially those younger than 50 years old, right sided and high-grade CRCs. |
| Databáze: | OpenAIRE |
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