The neurotrophin network in human skin

Autor: Carlo Pincelli, Paola Atzei, Alessandra Marconi, M. Dumas, Marco Pignatti, Alberto Giannetti, Francesca Truzzi, F. Bonte, Chiara Fila
Rok vydání: 2008
Předmět:
Zdroj: Experimental Dermatology. 13:588-588
ISSN: 0906-6705
Popis: The neurotrophin (NT) family includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4/5. Keratinocytes synthesize and release all NTs. Keratinocytes express the low-affinity p75 receptor which binds all NTs, the high-affinity NGF receptor trkA and the NT-3 receptor trkC. By contrast, keratinocytes express only a truncated form of trkB, the BDNF high-affinity receptor. NT-3 stimulates keratinocyte proliferation. NTs other than NGF fail to protect keratinocytes from UVB-induced apoptosis. While NGF decreases upon UVB irradiation, NT-3 and NT-4 are upregulated. UVA dose dependently increases NT-3 levels. NT-3 and NGF stimulate each other release. Both fibroblasts and myofibroblasts synthesize and release all NTs, as well as their trk receptors except for trkC. p75 is more expressed in myofibroblast than in fibroblasts. NGF reduces secretion of collagen I in myofibroblasts. Myofibroblasts secrete more collagen I than fibroblasts. NGF reduces production of metalloproteinase 2 (MMP2) in myofibroblasts. Melanocytes synthesize and release all NTs. UVB irradiation upregulates the release of NT-3, while it downregulates the release of NT-4. Melanocytes express p75, which is downregulated by UVB. Melanocytes also express trkA and the extracellular domain of trkB. Taken together, these data indicate that a complex NT network exists in human skin with potential functions, partly to be determined.
Databáze: OpenAIRE
Externí odkaz: