Impact of rotavirus vaccination on the burden of acute gastroenteritis in Nagoya city, Japan
| Autor: | Tetsushi Yoshikawa, Makoto Morita, Kusuma Gopala, Mitsuji Iwasa, Motohiro Shibata, Taizo Matsuki, Mihoko Mizuno, Katsiaryna Holl, Keiko Sato, Shinji Hasegawa |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Rotavirus 0301 basic medicine Pediatrics medicine.medical_specialty 030106 microbiology Rotavirus gastroenteritis Rotavirus vaccination medicine.disease_cause Rotavirus Infections 03 medical and health sciences 0302 clinical medicine Cost of Illness Japan Age groups Ambulatory Care Humans Medicine Public Health Surveillance 030212 general & internal medicine Retrospective Studies General Veterinary General Immunology and Microbiology business.industry Incidence Vaccination Infant Newborn Rotavirus Vaccines Public Health Environmental and Occupational Health Infant Acute gastroenteritis Gastroenteritis Hospitalization Infectious Diseases Outpatient visits Child Preschool Herd Molecular Medicine Female business |
| Zdroj: | Vaccine. 36:527-534 |
| ISSN: | 0264-410X |
| Popis: | In Nagoya city, Japan, rotavirus (RV) vaccination has been available since 2011 with estimated coverage reaching 92% by 2015 after the introduction of a public subsidy in 2012. This study assessed the impact of vaccination on the RV gastroenteritis (RVGE) burden in children aged5 years old (y) by comparing RVGE hospitalizations and outpatient visits during pre-vaccination (2007-2011), transition (2011-2012) and subsidization (2012-2016) periods.All hospitalizations and outpatient visits in children aged5 y from 2 administrative districts of Nagoya city were identified from the hospital-based electronic databases of 4 hospitals. RVGE cases were identified by diagnostic code and/or positive results of diagnostic kits.Compared to the pre-vaccination period, there was a decrease in RVGE hospitalizations for children5 y from 5.59 per 1000 person-year (kPY) to 3.65/kPY in the subsidization period (i.e. 34.69%). In children1 y, the incidence of RVGE hospitalizations decreased continuously from 6.62/kPY in the pre-vaccination period to 1.84/kPY in the subsidization period (i.e. 72.19%). The highest decrease was observed in the subsidization season i.e. when high coverage was reached: 69% and 75.57% in the 2013/2014 season for 2-3 y and 3-4 y, and 74.03% in the 2014/2015 season for 4-5 y, respectively. Proportion of RVGE outpatient visits decreased by 87.44% for children1 y and 57.05% for5 y from the pre-vaccination to the subsidization period. This decrease started the first year of subsidization for children1 y, 1-2 y and 2-3 y (78.89%, 18.86% and 5.80%) and the second year (2013/2014 season) for children 3-4 y and 4-5 y (87.73% and 51.78%).Although yearly fluctuations have been observed, the introduction of vaccination significantly decreased pediatric RVGE hospitalizations and outpatient visits, especially in the age group eligible for vaccination. During the second and third year of subsidization, we observed a herd protection effect on other age groups5 y who were not eligible for vaccination. Clinicaltrial.gov.registered#:NCT01733862. |
| Databáze: | OpenAIRE |
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