Skeletal complications of ADT: disease burden and treatment options
| Autor: | Juan Morote Robles, Jacques Planas Morin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Bone density Urology Osteoporosis Bone Neoplasms Review law.invention Prostate cancer Randomized controlled trial Bone Density law medicine Humans Toremifene Intensive care medicine Adverse effect Diphosphonates business.industry Prostatic Neoplasms Androgen Antagonists General Medicine Bone fracture medicine.disease Surgery Denosumab business medicine.drug |
| Zdroj: | Asian Journal of Andrology. 14:670-675 |
| ISSN: | 1745-7262 1008-682X |
| Popis: | Therapy based on androgenic deprivation is one of the standard treatments that many prostate cancer patients receive. Moreover, its use is increasing owing to a clear expansion of the indications for this therapy in patients with localized prostate cancer. Despite classically being considered to be well tolerated, androgenic deprivation has adverse effects. Of these, the loss of mineral bone mass is particularly notable and can lead to osteoporosis, as well as an increased risk of bone fracture. Some fractures, such as hip fractures, may have serious consequences. Useful procedures such as bone densitometry can aid in the diagnosis of these conditions. Once diagnosed, decreases in mineral bone mass can be managed by dietary recommendations, general changes in lifestyle or medication. We review the most important randomized controlled trials evaluating different drugs (bisphosphonates, denosumab and toremifene) in the prevention of bone loss and in the reduction in fracture risk in prostate cancer patients treated with androgen-deprivation therapy. Following the applicable recommendations, urologists must carefully monitor the bone health of prostate cancer patients subjected to androgenic deprivation to obtain an early diagnosis and apply the appropriate general and/or therapeutic measures if necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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