Prenatal exposures and birth indices, and subsequent risk of polycystic ovary syndrome: a national registry‐based cohort study
| Autor: | Heiddis Valgeirsdottir, Olof Stephansson, Tone S. Løvvik, Eszter Vanky, Inger Sundström-Poromaa, Anna-Karin Wikström, Nathalie Roos |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent endocrine system diseases media_common.quotation_subject Prenatal care Article Body Mass Index Cigarette Smoking Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Birth Weight Humans Obesity Registries Girl Proportional Hazards Models media_common Sweden 030219 obstetrics & reproductive medicine Obstetrics business.industry nutritional and metabolic diseases Obstetrics and Gynecology Polycystic ovary female genital diseases and pregnancy complications Pregnancy Complications Population Surveillance Prenatal Exposure Delayed Effects Infant Small for Gestational Age Cohort Female National registry business Body mass index Polycystic Ovary Syndrome Cohort study |
| Zdroj: | BJOG: an International Journal of Obstetrics and Gynaecology |
| ISSN: | 1471-0528 1470-0328 |
| DOI: | 10.1111/1471-0528.15236 |
| Popis: | Objective To study the associations between prenatal exposures and risk of developing polycystic ovary syndrome (PCOS). Design National registry‐based cohort study. Setting Sweden. Population Girls born in Sweden during the years 1982–1995 (n = 681 123). Methods The girls were followed until the year 2010 for a diagnosis of PCOS. We estimated the associations between maternal body mass index (BMI), smoking, and size at birth with the risk of developing a PCOS diagnosis. Risks were calculated by adjusted hazard ratio (aHR) and 95% confidence intervals (95% CIs). Main outcome measures A diagnosis of PCOS at 15 years of age or later. Results During the follow‐up period 3738 girls were diagnosed with PCOS (0.54%). Girls with mothers who were overweight or obese had 1.5–2.0 times higher risk of PCOS (aHR 1.52, 95% CI 1.36–1.70; aHR 1.97, 95% CI 1.61–2.41, respectively), compared with girls born to mothers of normal weight. The risk of PCOS was increased if the mother smoked during pregnancy (1–9 cigarettes/day, aHR 1.31, 95% CI 1.18–1.47; ≥10 cigarettes/day, aHR 1.44, 95% CI 1.27–1.64). Being born small for gestational age (SGA) was associated with a later diagnosis of PCOS in crude estimates, but the association was not significant after adjusting for maternal factors. Conclusions Maternal smoking and increased BMI appear to increase the risk of PCOS in offspring. The association between SGA and the development of PCOS appears to be mediated by maternal factors. Tweetable abstract Smoking during pregnancy and high maternal BMI are associated with PCOS diagnosis in the offspring. This is the peer reviewed version of an article, which has been published in final form at [https://doi.org/10.1111/1471-0528.15245]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Databáze: | OpenAIRE |
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