Clonal complex 398 methicillin-susceptible Staphylococcus aureus bloodstream infections are associated with high mortality
| Autor: | Didier Hocquet, Pascal Cholley, Houssein Gbaguidi-Haore, Xavier Bertrand, Kevin Bouiller, Catherine Chirouze |
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| Přispěvatelé: | Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Service d’Hygiène Hospitalière, Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Pediatrics medicine.medical_specialty Staphylococcus aureus Genotype 030106 microbiology Staphylococcal infections medicine.disease_cause Hospitals University 03 medical and health sciences Methicillin Risk Factors [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology Sepsis Medicine Humans Survival analysis ComputingMilieux_MISCELLANEOUS Aged Aged 80 and over Molecular Epidemiology Molecular epidemiology business.industry Incidence (epidemiology) Incidence Case-control study General Medicine Odds ratio Middle Aged Staphylococcal Infections medicine.disease Survival Analysis 3. Good health Anti-Bacterial Agents Molecular Typing [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Infectious Diseases Case-Control Studies Female France business Methicillin Susceptible Staphylococcus Aureus |
| Zdroj: | Clinical Microbiology and Infection Clinical Microbiology and Infection, Wiley, 2016 Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2016 |
| ISSN: | 1198-743X 1469-0691 |
| Popis: | Within the last decade, methicillin-resistant Staphylococcus aureus belonging to clonal complex 398 (CC398) has become a worldwide threat associated with livestock. More recently, methicillin-susceptible S. aureus (MSSA) belonging to CC398 have been increasingly reported as a cause of invasive infections in patients without livestock contact. We investigated risk factors associated with CC398 bloodstream infections (BSIs) compared with non-CC398 BSIs with a case-control study in a French university Hospital. From January 2010 to December 2014, nonduplicate Staphylococcus aureus (SA) isolates responsible for BSIs in adult patient were typed to identify those belonging to CC398. Each adult patient with a CC398 SA BSI (cases) was matched with 2 non-CC398 SA BSI controls randomly selected on the basis of the time at risk, the unit of hospitalization and susceptibility to methicillin. We retrospectively extracted the clinical information from electronic medical records and used conditional logistic regression for univariate and multivariate analyses. We identified 67 CC398 isolates among the 770 SA responsible for BSI in adult patients. All CC398 isolates were susceptible to methicillin. The proportion of CC398 among MSSA increased steadily from 4.6% in 2010 to 15.1% in 2013 and then stabilized at 13.8% in 2014. Factors significantly associated with CC398 MSSA BSIs were healthcare-associated infection (odds ratio (OR) 3.02, 95% confidence interval (CI) 1.19-7.63), history of neurologic disease (OR 2.51, 95% CI 1.13-5.65) and 30-day mortality (OR 2.44, 95% CI 1.23-4.85). |
| Databáze: | OpenAIRE |
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