Enhanced reactive oxygen species through direct copper sulfide nanoparticle-doxorubicin complexation
| Autor: | Julie Scott, Wei Lu, Michela Cupo, Bingfang Yan, Yajuan Li, Yi-Tzai Chen, Liangran Guo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Cell Survival Infrared Rays Drug Compounding Inorganic chemistry Kinetics Static Electricity Nanoparticle Bioengineering Antineoplastic Agents macromolecular substances 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Polyethylene Glycols chemistry.chemical_compound polycyclic compounds medicine Humans General Materials Science Doxorubicin Chelation Electrical and Electronic Engineering chemistry.chemical_classification Reactive oxygen species Drug Carriers organic chemicals Mechanical Engineering Lasers technology industry and agriculture General Chemistry Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences carbohydrates (lipids) Copper sulfide Drug Liberation chemistry Mechanics of Materials A549 Cells Nanoparticles 0210 nano-technology Drug carrier Reactive Oxygen Species Copper medicine.drug |
| Zdroj: | Nanotechnology. 28(50) |
| ISSN: | 1361-6528 |
| Popis: | CuS-based nanostructures loading the chemotherapeutic agent doxorubicin (DOX) exerted excellent cancer photothermal chemotherapy under multi-external stimuli. The DOX loading was generally designed through electrostatic interaction or chemical linkers. However, the interaction between DOX molecules and CuS nanoparticles has not been investigated. In this work, we use PEGylated hollow copper sulfide nanoparticles (HCuSNPs) to directly load DOX through the DOX/Cu2+ chelation process. Distinctively, the synthesized PEG-HCuSNPs-DOX release the DOX/Cu2+ complexes into surrounding environment, which generate significant reactive oxygen species (ROS) in a controlled manner by near-infrared laser. The CuS nanoparticle-mediated photothermal ablation facilitates the ROS-induced cancer cell killing effect. Our current work reveals a DOX/Cu2+-mediated ROS-enhanced cell-killing effect in addition to conventional photothermal chemotherapy through the direct CuS nanoparticle-DOX complexation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|