Incidence, Mortality, and Disease Associations of Pyoderma Gangrenosum in the United Kingdom: A Retrospective Cohort Study
Autor: | Richard Groves, Sinead Langan, Martin Gulliford, Timothy R. Card |
---|---|
Jazyk: | angličtina |
Předmět: |
Adult
Male Risk medicine.medical_specialty Adolescent Databases Factual Population Dermatology Biochemistry Arthritis Rheumatoid Young Adult Interquartile range Internal medicine Epidemiology medicine Humans Child education Molecular Biology Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Incidence Incidence (epidemiology) Hazard ratio Retrospective cohort study Cell Biology Middle Aged Inflammatory Bowel Diseases medicine.disease Hematologic Diseases Pyoderma Gangrenosum United Kingdom Confidence interval Surgery Female business Pyoderma gangrenosum |
Zdroj: | Journal of Investigative Dermatology. (9):2166-2170 |
ISSN: | 0022-202X |
DOI: | 10.1038/jid.2012.130 |
Popis: | Pyoderma gangrenosum (PG) is an important disease with significant complications. The objectives of this study were to determine incidence and mortality of PG and strength of reported associations. A retrospective cohort study was completed using computerized medical records from the General Practice Research Database, a large representative UK database. Patients with PG and three groups of age-, sex-, and practice-matched controls--general population, rheumatoid arthritis (RA), and inflammatory bowel disease (IBD) controls--were included in the study. Incidence and mortality were determined and validation undertaken to inform diagnostic accuracy. In all there were 313 people with the median age of 59 (interquartile range 41-72) years, and of them 185 (59%) were female. The adjusted incidence rate standardized to European standard population was 0.63 (95% confidence interval (CI) 0.57-0.71) per 100,000 person-years. The risk of death was three times higher than that for general controls (adjusted hazard ratio=3.03, 95% CI 1.84-4.73, P |
Databáze: | OpenAIRE |
Externí odkaz: |