Short-Term Retinal Sensitivity and Metamorphopsia Changes following Half-Fluence Photodynamic Therapy in Central Serous Chorioretinopathy
| Autor: | Federico Corvi, Giuseppe Casalino, Francesco Bandello, Claudia Del Turco, Omer Rafaeli, Giuseppe Querques |
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| Přispěvatelé: | Casalino, G, Del Turco, C, Corvi, F, Rafaeli, O, Bandello, Francesco, Querques, Giuseppe |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Time Factors Visual acuity chemistry.chemical_compound 0302 clinical medicine Prospective Studies Fluorescein Angiography Photosensitizing Agents medicine.diagnostic_test General Medicine Diabetic retinopathy Middle Aged Fluorescein angiography Verteporfin Sensory Systems Preferential hyperacuity perimetry Treatment Outcome Central Serous Chorioretinopathy Female medicine.symptom Tomography Optical Coherence medicine.drug Adult medicine.medical_specialty Porphyrins Fundus Oculi Vision Disorders Retina 03 medical and health sciences Cellular and Molecular Neuroscience Ophthalmology medicine Humans Metamorphopsia Aged Dose-Response Relationship Drug business.industry Retinal medicine.disease 030104 developmental biology Photochemotherapy chemistry 030221 ophthalmology & optometry Visual Field Tests Visual Fields business Microperimetry Follow-Up Studies |
| Popis: | Purpose: The aim of this study was to investigate the short-term retinal sensitivity and metamorphopsia changes after half-fluence photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC). Methods: Patients with acute CSC and evidence of angiographic leakage and subretinal fluid on optical coherence tomography (OCT) were enrolled. Before, and 1 week (W-1) and 2 months (M-2) after PDT, all patients underwent best-corrected visual acuity, enhanced depth imaging OCT, microperimetry (MP) and preferential hyperacuity perimetry (PHP). We considered 'affected' the Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors showing a mean retinal thickness greater than 350 mu m on the baseline OCT thickness map. MP retinal sensitivity, PHP 'score' and retinal thickness were measured in each ETDRS 'affected sector'. Functional correlation be-tween MP and PHP was also investigated. Results: Twelve eyes of 12 patients were included. MP and PHP correlated with each other at baseline (p = 0.04) but not at W-1 (p = 0.12) and M-2 (p = 0.05). Mean MP retinal sensitivity slightly improved from 12.9 +/- 5.0 dB at baseline to 14.5 +/- 4.7 dB at M-2 (p = 0.2).The PHP score changed from 0.33 at baseline to 0.32 at M-2 (p = 0.3). In the ETDRS 'affected sectors', MP retinal sensitivity improved significantly from 12.9 +/- 5.0 dB at baseline to 14.5 +/- 4.7 dB at M-2 (p = 0.03), whereas the PHP score did not show significant changes over time. Conclusion: Half-fluence PDT achieved short-term improvement in the sensitivity of the retinal 'affected sectors' but did not influence metamorphopsia as measured on PHP in patients with acute CSC. (C) 2016 S. Karger AG, Basel Purpose: The aim of this study was to investigate the short-term retinal sensitivity and metamorphopsia changes after half-fluence photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC). Methods: Patients with acute CSC and evidence of angiographic leakage and subretinal fluid on optical coherence tomography (OCT) were enrolled. Before, and 1 week (W-1) and 2 months (M-2) after PDT, all patients underwent best-corrected visual acuity, enhanced depth imaging OCT, microperimetry (MP) and preferential hyperacuity perimetry (PHP). We considered 'affected' the Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors showing a mean retinal thickness greater than 350 mu m on the baseline OCT thickness map. MP retinal sensitivity, PHP 'score' and retinal thickness were measured in each ETDRS 'affected sector'. Functional correlation be-tween MP and PHP was also investigated. Results: Twelve eyes of 12 patients were included. MP and PHP correlated with each other at baseline (p = 0.04) but not at W-1 (p = 0.12) and M-2 (p = 0.05). Mean MP retinal sensitivity slightly improved from 12.9 +/- 5.0 dB at baseline to 14.5 +/- 4.7 dB at M-2 (p = 0.2).The PHP score changed from 0.33 at baseline to 0.32 at M-2 (p = 0.3). In the ETDRS 'affected sectors', MP retinal sensitivity improved significantly from 12.9 +/- 5.0 dB at baseline to 14.5 +/- 4.7 dB at M-2 (p = 0.03), whereas the PHP score did not show significant changes over time. Conclusion: Half-fluence PDT achieved short-term improvement in the sensitivity of the retinal 'affected sectors' but did not influence metamorphopsia as measured on PHP in patients with acute CSC. (C) 2016 S. Karger AG, Basel |
| Databáze: | OpenAIRE |
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