Boron-containing acids: preliminary evaluation of acute toxicity and access to the brain determined by Raman scattering spectroscopy
| Autor: | Yessica López-Cabrera, Marvin A. Soriano-Ursúa, José G. Trujillo-Ferrara, Enrique Querejeta, Eunice D. Farfán-García |
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| Rok vydání: | 2013 |
| Předmět: |
Male
General Neuroscience Lethal dose Brain Mice Inbred Strains Pharmacology Motor Activity Toxicology Spectrum Analysis Raman Median lethal dose Effective dose (pharmacology) Boronic Acids Acute toxicity Lethal Dose 50 chemistry.chemical_compound Mice chemistry Drug development Biochemistry Potency Animals Phenylboronic acid Chronic toxicity |
| Zdroj: | Neurotoxicology. 40 |
| ISSN: | 1872-9711 |
| Popis: | Boron-containing compounds (BCCs), particularly boron containing acids (BCAs), have become attractive moieties or molecules in drug development. It has been suggested that when functional groups with boron atoms are added to well-known drugs, the latter are conferred with greater potency and efficacy in relation to their target receptors. However, the use of BCAs in drug development is limited due to the lack of a toxicological profile. Consequently, the aim of the present study was to evaluate the acute toxicity of boric and boronic acids. Thus, a determination was made of the lethal dose (LD50) of test compounds in male CD1 mice, as well as the effective dose required to negatively affect spontaneous motor activity and to produce notable behavioral abnormalities. After treatment of animals at different doses, macroscopic observations were made from a necropsy, and Raman scattering spectroscopic studies were carried out on brain tissue samples. In general, the results show that most of the tested BCAs have very low toxicity, evidenced by the high doses required to induce notable toxic effects (greater than 100 mg/kg of body weight for all compounds, except for 3-thyenilboronic acid). Such toxic effects, presumably mediated by action on the CNS, include eye damage, gastrointestinal effects (e.g., gastric-gut dilatation and fecal retention), sedation, hypnosis and/or trembling. This preliminary toxicological profile suggests that BCAs can be considered potential therapeutic agents or moieties to be added to other compounds in the development of new drugs. Future studies are required to explore possible chronic toxicity of BCCs. |
| Databáze: | OpenAIRE |
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