Temozolomide with or without Radiotherapy in Patients with Newly Diagnosed Glioblastoma Multiforme: A Meta-Analysis
| Autor: | Changbai Sui, Gaoling Sun, Enshan Feng, Tongxin Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Male Disease free survival medicine.medical_specialty medicine.medical_treatment MEDLINE Newly diagnosed Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Temozolomide Medicine Humans In patient Antineoplastic Agents Alkylating Aged Radiotherapy business.industry Brain Neoplasms Middle Aged medicine.disease Combined Modality Therapy Radiation therapy Dacarbazine Neurology 030220 oncology & carcinogenesis Meta-analysis Female Neurology (clinical) business Glioblastoma 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European neurology. 77(3-4) |
| ISSN: | 1421-9913 |
| Popis: | Background/Aim: The current meta-analysis evaluated the survival outcomes of newly diagnosed glioblastoma patients treated with radiotherapy (RT) alone and with RT + temozolomide (TMZ). Methods: Relevant studies were identified by an extensive literature search in Medline, Current Contents and Cochrane databases by 2 independent reviewers using the terms “glioblastoma multiforme/glioblastoma, TMZ, radiation therapy/RT and survival.” Results: Results revealed a median survival of 13.41-19 months in the combined treatment group, as opposed to 7.7-17.1 months in the RT-alone group. Progression-free survival (PFS) was also significantly different between the 2 groups (RT + TMZ, 6.3-13 months; RT-alone, 5-7.6 months). While there was no significant difference in the 6-month survival and 6-month PFS rates between the RT + TMZ and RT groups (pooled OR 0.690; p = 0.057 and OR 0.429, p = 0.052, respectively), the 1-year survival and 1-year PFS rates showed significant difference (OR 0.469; p = 0.030 and OR 0.245, p < 0.001, respectively). Conclusions: Concomitant RT + TMZ is more effective and improves the overall survival and PFS in patients with newly diagnosed glioblastoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|