Cross-tolerance of dopamine metabolism to baclofen, γ-butyrolactone and HA-966 in the striatum and olfactory tubercle of the rat
| Autor: | Erik L. Noach, Henk J. Broxterman, Cees F.M. Van Valkenburg, Amerentia Wijling |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Baclofen medicine.medical_specialty Apomorphine Dopamine Nigrostriatal pathway Striatum General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound 4-Butyrolactone Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Olfactory tubercle Homovanillic acid Central Nervous System Depressants Drug Tolerance General Medicine Olfactory Bulb Corpus Striatum Pyrrolidinones Rats Cross-tolerance medicine.anatomical_structure Endocrinology nervous system chemistry medicine.drug |
| Zdroj: | Life Sciences. 28:973-981 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90742-6 |
| Popis: | Rats received 7 daily injections with baclofen (40 mg/kg), GBL (750 mg/kg) or HA-966 (100 mg/kg). Dopamine (DA) was measured in the striatum and olfactory tubercle (OT) of rats, sacrificed 0.5 h or 1 h after the last injection. Marked tolerance and cross-tolerance for the DA-elevating effect of these drugs was seen in the striatum, but not in OT. When on day 7 a unilateral lesion of the nigrostriatal pathway was made, also some tolerance to the DA increase in the striatum on the lesioned side was seen in HA-966-pretreated rats, but it was small compared to the tolerance after an additional drug administration in non-lesioned animals. A low dose of apomorphine (0.25 mg/kg, i.p.) had no effect on DA, dihydroxyphenylacetic acid DOPAC) or homovanillic acid (HVA) levels in the lesioned striata, whether the rats had been pretreated for 6 days with HA-966 or not. However, this dose of apomorphine had a significantly more lowering effect on striatal DOPAC and HVA levels on the unlesioned side of HA-966 pretreated rats. The results show that tolerance develops to the increase of DA synthesis, which is possibly receptor-mediated. This tolerance develops more readily in the striatum than in the olfactory tubercle. |
| Databáze: | OpenAIRE |
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