Urinary Epidermal Growth Factor/Creatinine Ratio and Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study
| Autor: | Stefan P Berger, Rijk O. B. Gans, Matthias Kretzler, Wenjun Ju, Gerjan Navis, Manuela Yepes-Calderón, Stephan J. L. Bakker, Camilo G. Sotomayor |
|---|---|
| Přispěvatelé: | Lifelong Learning, Education & Assessment Research Network (LEARN), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
CHRONIC ALLOGRAFT FAILURE Urinary system graft failure BIOMARKERS 030232 urology & nephrology Urology lcsh:Medicine Renal function BLOOD-PRESSURE PROGRESSION Urine 030204 cardiovascular system & hematology renal transplantation DISEASE Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine KIDNEY medicine Prospective cohort study EGF Kidney Creatinine EXCRETION Proteinuria biology business.industry lcsh:R C-reactive protein creatinine General Medicine C-REACTIVE PROTEIN 3. Good health medicine.anatomical_structure epidermal growth factor chemistry FACTOR RECEPTOR biology.protein medicine.symptom business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 8, Iss 10, p 1673 (2019) Journal of Clinical Medicine, 8(10):1673. MDPI AG Volume 8 Issue 10 |
| ISSN: | 2077-0383 |
| Popis: | Graft failure (GF) remains a significant limitation to improve long-term outcomes in renal transplant recipients (RTR). Urinary epidermal growth factor (uEGF) is involved in kidney tissue integrity, with a reduction of its urinary excretion being associated with fibrotic processes and a wide range of renal pathologies. We aimed to investigate whether, in RTR, uEGF is prospectively associated with GF. In this prospective cohort study, RTR with a functioning allograft &ge 1-year were recruited and followed-up for three years. uEGF was measured in 24-hours urine samples and normalized by urinary creatinine (Cr). Its association with risk of GF was assessed by Cox-regression analyses and its predictive ability by C-statistic. In 706 patients, uEGF/Cr at enrollment was 6.43 [IQR 4.07&ndash 10.77] ng/mg. During follow-up, 41(6%) RTR developed GF. uEGF/Cr was inversely associated with the risk of GF (HR 0.68 [95% CI 0.59&ndash 0.78] P < 0.001), which remained significant after adjustment for immunosuppressive therapy, estimated Glomerular Filtration Rate, and proteinuria. C-statistic of uEGF/Cr for GF was 0.81 (P < 0.001). We concluded that uEGF/Cr is independently and inversely associated with the risk of GF and depicts strong prediction ability for this outcome. Further studies seem warranted to elucidate whether uEGF might be a promising marker for use in clinical practice. |
| Databáze: | OpenAIRE |
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