Isolated perfusion of pancreas with mitomycin C
| Autor: | Mark A. Arredondo, Neil R. Thomford, Bina Chaudhuri, Prabir K. Chaudhuri, Keith A. Crist, Rita Kar |
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| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Duodenum medicine.medical_treatment Mitomycin Urology Mitomycins Leukocyte Count Dogs Pharmacokinetics Pancreatic cancer medicine Animals Pancreas Chromatography High Pressure Liquid Chemotherapy business.industry Mitomycin C General Medicine Lipase medicine.disease Surgery Pancreatic Neoplasms medicine.anatomical_structure Chemotherapy Cancer Regional Perfusion Toxicity Amylases Lymph Nodes business Perfusion |
| Zdroj: | American journal of surgery. 159(6) |
| ISSN: | 0002-9610 |
| Popis: | The current treatment of pancreatic cancer with resection and/or radiation is considered unsatisfactory because of a high incidence of failure and a moderate incidence of complications. A sizable number of these patients present with localized or regional disease. Regional high-dose chemotherapy, such as with isolated perfusion, may offer an alternative therapy with low treatment-related morbidity and mortality and better end results in this group of patients. In an effort to develop such a treatment modality, we evaluated the pharmacokinetics and toxicity of mitomycin C (MMC) during isolated perfusion of pancreas in a canine model. From this study, it appears that a dose of 0.25 mg MMC/kg body weight is most suitable for isolated perfusion of pancreas at 39 degrees C, maintaining flow rate and pressure within physiologic range. Isolated perfusion with a dose of 0.25 mg/kg body weight has very mild short- and long-term toxicities and markedly increases drug delivery to the pancreas, duodenum, and peripancreatic lymph nodes, making it the most suitable dose for possible clinical application. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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