Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1–5: a cross-sectional study of the Copenhagen chronic kidney disease cohort

Autor: Bo Feldt-Rasmussen, Anne-Lise Kamper, Philip Brainin, Nicholas Carlson, Susanne Bro, Christina Christoffersen, Klaus F. Kofoed, Ellen Linnea Freese Ballegaard, Ida M. H. Sørensen, Sasha Asbøll Kepler Saurbrey, Henrik Øder Hjortkjær
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Carotid Artery Diseases
Male
Denmark
medicine.medical_treatment
Coronary Artery Disease
lcsh:RC870-923
Severity of Illness Index
RISK MARKERS
Chronic kidney disease
Prevalence
Thoracic aorta
Aorta
Vascular calcification
education.field_of_study
Abdominal aorta
DEATH
Middle Aged
Cardiovascular disease
Coronary Vessels
Calcium score
Carotid arteries
Arterial calcification
medicine.anatomical_structure
Nephrology
Cardiology
Female
Research Article
CALCIFIED ATHEROSCLEROSIS
Adult
medicine.medical_specialty
Population
Aortic Diseases
IMPROVEMENT
Iliac Artery
CALCIUM
Coronary arteries
VASCULAR CALCIFICATION
Internal medicine
medicine.artery
Multidetector Computed Tomography
SCORE
Iliac arteries
medicine
Humans
Renal Insufficiency
Chronic
education
Dialysis
Aged
business.industry
BEDS
QUANTIFICATION
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Logistic Models
Multivariate Analysis
Kidney Failure
Chronic
business
Kidney disease
Calcification
Zdroj: BMC Nephrology, Vol 21, Iss 1, Pp 1-11 (2020)
Sorensen, I M H, Saurbrey, S A K, Hjortkjaer, H O, Brainin, P, Carlson, N, Ballegaard, E L F, Kamper, A-L, Christoffersen, C, Feldt-Rasmussen, B, Kofoed, K F & Bro, S 2020, ' Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1-5 : a cross-sectional study of the Copenhagen chronic kidney disease cohort ', BMC Nephrology, vol. 21, no. 1, 534 . https://doi.org/10.1186/s12882-020-02192-y
BMC Nephrology
ISSN: 1471-2369
DOI: 10.1186/s12882-020-02192-y
Popis: Background Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD. Methods This was an observational, cross-sectional study that included 580 individuals with CKD stages 1–5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1–100, 101–400 and > 400. Results Participants with CKD stages 3–5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only. Conclusions Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.
Databáze: OpenAIRE
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