A pyrazine amide-4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities
| Autor: | Ida Bergare, Magda Monari, Pete Smith, Ebbe Nordlander, Josefine Hansson, Bhavna G. Gordhan, Isa Doverbratt, Carmen de Kock, Erik Ekengard, Bavesh D. Kana |
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| Přispěvatelé: | Ekengard, E, Bergare, I, Hansson, J, Doverbratt, I, Monari, M, Gordhan, B, Kana, B, de Kock, C, Smith, PJ, Nordlander, E |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
pyrazinamide
Pyrazine half-sandwich complexe 010405 organic chemistry Ligand Stereochemistry organometallic chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Malaria Aminoquinoline chloroquine chemistry.chemical_compound chemistry Cyclopentadienyl complex 4-Aminoquinoline Hexafluorophosphate Amide medicine Iridium tuberculosi medicine.drug |
| Popis: | The synthesis and characterization of N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline – pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*) Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented. |
| Databáze: | OpenAIRE |
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